Abstract
Cardiac output measurements were performed during 50 exercise tests in 16 normal subjects employing the indirect Fick principle for CO2. During sub-maximal steady state exercise the plateau CO2 tension (\(P_{plat CO_2 } \)) was estimated with a rebreathing procedure. The mixed venous CO2 tension (\(P_{\bar v CO_2 } \)) was calculated by subtracting the alveolocapillary CO2 tension difference from the\(P_{plat CO_2 } \). Compared with data from the literature the most valid calculation of the cardiac output was obtained by using the\(P_{\bar v CO_2 } \). Cardiac output values, calculated via the\(P_{plat CO_2 } \) turned out to be too low.
The reproducibility was tested by repitition of 18 exercise tests at least after 5 days. The relative standard error of a single observation was 4.1% for the cardiac output, which was found to be as good as that of invasive measurements.
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Asmussen, E., Nielsen, M.: Physiological dead space and alveolar gas pressures at rest and during muscular exercise. Acta Physiol. Scand.38, 3–21 (1956)
Åstrand, P.-O., Cuddy, T. E., Saltin, B., Stenberg, J.: Cardiac output during submaximal and maximal work. J. Appl. Physiol.19, 268–274 (1964)
Bevegård, B. S., Holmgren, A., Jonsson, B.: The effect of body position on the circulation at rest and during exercise, with special reference to the influence on the stroke volume. Acta Physiol. Scand.49, 279–298 (1960)
Collier, C. R.: Determination of mixed venous CO2 tensions by rebreathing. J. Appl. Physiol.9, 25–29 (1956)
Doll, E., Keul, J., Maiwald, C., Reindell, H.: Das Verhalten von Sauerstoffdruck, Kohlensäuredruck, pH, Standarbicarbonat und Base Excess im arteriellen Blut bei verschiedenen Belastungsformen. Int. Z. Angew. Physiol. einschl. Arbeitsphysiol.22, 327–355 (1966)
Ekelund, L. G., Holmgren, A.: Central haemodynamics during exercise. Circ. Res. 20, Suppl.1, 33–43 (1967)
Godfrey, S.: Manipulation of the indirect Fick principle b0059-0307 a digital computer program for the calculation of exercise physiology results. Respiration27, 513–523 (1970)
Godfrey, S., Wolf, E.: An evaluation of rebreathing methods for measuring a mixed venous\(P_{{\text{CO}}_{\text{2}} } \) during exercise. Clin. Sci.42, 345–353 (1972)
Hermansen, L., Ekblom, B., Saltin, B.: Cardiac output during submaximal and maximal treadmill and bicycle exercise. J. Appl. Physiol.29, 82–86 (1970)
van Herwaarden, C. L. A.: Selective and non-selective β-blockade in hypertension. A study of the effects of adrenaline and exercise on haemodynamics with emphasis on cardiac output measurement by way of the CO2 rebreathing method. Thesis, chapter 2, Krips Repro Meppel 1978
Holmgren, A., Pernow, B.: The reproducibility of cardiac output determination by the direct Fick method during muscular work. Scand. J. Clin. Lab. Invest.12, 224–227 (1960)
Jones, N. L., Campbell, E. J. M., McHardy, G. J. R., Higgs, B. E., Clode, M.: The estimation of carbon dioxide pressure of mixed venous blood during exercise. Clin. Sci.32, 311–327 (1967)
Jones, N. L., Robertson, D. G., Kane, J. W., Campbell, E. J. M.: Effect of\(P_{{\text{CO}}_{\text{2}} } \) level on alveolar-arterial\(P_{{\text{CO}}_{\text{2}} } \) difference during rebreathing. J. Appl. Physiol.32, 782–787 (1972)
Paterson, D. H., Cunningham, D. A.: Camparison of methods to calculate cardiac output using the CO2 rebreathing method. Europ. J. Appl. Physiol.35, 223–230 (1976)
Rowell, L. B.: Circulation. Med. Sci. Sports1, 15–22 (1969)
Sannerstedt, R.: Hemodynamic response to exercise in patients with arterial hypertension. Acta Med. Scand, Suppl.458 (1966)
Zeidifard, E., Silverman, S., Godfrey, S.: Reproducibility of indirect CO2 Fick method for calculation of cardiac output. J. Appl. Physiol.33, 141–143 (1972)
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van Herwaarden, C.L.A., Binkhorst, R.A., Fennis, J.F.M. et al. Reliability of the cardiac output measurement with the indirect Fick-principle for CO2 during exercise. Pflügers Arch. 385, 21–23 (1980). https://doi.org/10.1007/BF00583910
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DOI: https://doi.org/10.1007/BF00583910