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Cyclic AMP and the potassium-induced vasodilation

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Summary

The cAMP concentration of bovine facial arteries (helical strips) increased from 0.84±0.14 to 1.51±0.24 nmole/g wet weight, when the strips were relaxed by exposure to a physiological salt solution containing 10 instead of 2.7 mM KCl. A similar result (increase from 1.13±0.15 to 2.07±0.29 nmole cAMP/g wet weight) was obtained in strips pretreated with 10−7 g/ml β-methyldigoxin. These strips reacted to 10 mM KCl with a constriction. Addition of the phosphodiesterase activator N-methyl-imidazole (3·10−3 M) did not affect the mechanical response to 10 mM KCl. It is concluded that for the potassium-induced vasodilation cAMP does not have a mediating function comparable to that in β-adrenergic relaxation of vascular smooth muscle.

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Nguyen-Duong, H., Brecht, K. & Gebert, G. Cyclic AMP and the potassium-induced vasodilation. Pflugers Arch. 356, 3–8 (1975). https://doi.org/10.1007/BF00583516

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