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Plasma and cerebrospinal fluid vasopressin and osmolality in relation to thirst

  • Transport Processes, Metabolism and Endocrinology; Kidney, Gastrointestinal Tract, and Exocrine Glands
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Abstract

Conscious dogs chronically implanted with a device for cerebrospinal fluid (CSF) sampling from the anterior 3rd ventricle were submitted to 24 h dehydration. During rehydration by drinking the total water intake (TWI) after 16 min was determined in 8 and after 90 min in 14 experiments. Samples were simultaneously drawn to determine the osmolalities (Posm, CSFosm) and AVP concentrations (PVVP, CSFAVP) of plasma and CSF. After 24 h dehydration all of these parameters were significantly elevated in comparison to euhydrated dogs investigated on 19 occasions. In 8 experiments 60% of the final TWI had been ingested within the first 16 min with no changes of Posm, CSFosm and CSFAVP, but a significant decrease of PAVP at this time. TWI per kg body weight (TWI·kg−1) after 90 min was significantly correlated with the osmolalities and AVP levels in plasma and CSF prior to rehydration. The decreases of Posm, CSFosm and PAVP, but not of CSFAVP, were significantly correlated with TWI·kg−1. The results indicate that PAVP and CSFAVP are subject to long term control by body fluid tonicity exhibiting a feedback relationship to water intake. In addition, PAVP but not CSFAVP seems to be under short term, possibly nonosmotic, control during water intake.

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Authors and Affiliations

  1. Max-Pianck-Institut für physiologische und klinische Forschung, W. G. Kerckhoff-Institut, D-6350, Bad Nauheim, Federal Republic of Germany

    Ewa Szczepańska-Sadowska, Christa Simon-Oppermann, David A. Gray & Eckhart Simon

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  1. Ewa Szczepańska-Sadowska
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  2. Christa Simon-Oppermann
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  3. David A. Gray
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  4. Eckhart Simon
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Supported by the Alexander von Humboldt-Foundation

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Szczepańska-Sadowska, E., Simon-Oppermann, C., Gray, D.A. et al. Plasma and cerebrospinal fluid vasopressin and osmolality in relation to thirst. Pflugers Arch. 400, 294–299 (1984). https://doi.org/10.1007/BF00581562

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  • DOI: https://doi.org/10.1007/BF00581562

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