Abstract
In order to evaluate whether alpha and beta adrenergic mechanisms participate in the coronary reactive hyperaemia, effects of phenoxybenzamine (10 mg per kg b.w.) or propranolol (2 mg per kg b.w.), or phenoxybenzamine + propranolol on reactive hyperaemic responses following 15, 30, 60 and 120 s occlusions of left coronary vessels were investigated on isolated fibrillating, blood-perfused dog heart preparations. Hearts were either perfused at constant pressure or at constant volume on the basal perfusion pressure of 150 mm Hg.
Phenoxybenzamine induced marked vasodilatation while the postocclusion reaction slightly increased when hearts were perfused at constant pressure. Upon application of propranolol both basal conductance and postocclusion reaction was considerably decreased. After phenoxybenzamine pretreatment propranolol did not change the maximum postocclusion coronary dilatation, but the duration of reactive hyperaemia however, was decreased.
It can be concluded that alpha and beta adrenergic receptors are involved in the regulation of coronary circulation of fibrillating canine heart either in the control state or during postocclusion period. Alpha receptors seem to determine the degree of coronary dilatation after the release of occlusion, while beta receptors may control primarily the duration of reactive hyperaemia.
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Farsang, C., Debreczeni, L., Kerényi, Á. et al. Effect of phenoxybenzamine and propranolol on myocardial reactive hyperaemia in fibrillating canine heart. Pflugers Arch. 379, 223–228 (1979). https://doi.org/10.1007/BF00581425
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DOI: https://doi.org/10.1007/BF00581425