Abstract
A simple and inexpensive device is decribed which generates voltage steps or cycles of steps of defined amplitude and duration either automatically (triggered by internal or computer clock pulses) or on manual command. The device facilitates the investigation of the voltage dependence of ion channel currents in patch-clamp experiments.
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References
Gitter AH, Zenner HP, Frömter E (1986) Membrane potential and ion channels in isolated outer hair cells of guinea pig cochlea. ORL J. Otorhinolaryngol Relat Spec 48:68–75
Gitter AH, Beyenbach KW, Christine C, Gross P, Frömter E (1986) K+-conductive channels in the apical membrane of principal cells cultured from rabbit cortical collecting duct. Pflügers Arch 406:R60
Hamill OP, Marty A, Neher E, Sakmann B, Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch 391:85–100
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Gitter, A.H., Theis, J. A low-cost voltage stepper device for use in patch-clamp experiments. Pflugers Arch. 408, 194–195 (1987). https://doi.org/10.1007/BF00581351
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DOI: https://doi.org/10.1007/BF00581351