Summary
The specific binding (Bmax) of (3H-methyl)yohimbine to alpha2-adrenoceptor binding sites on intact platelets was increased by 43% in 6 out of 7 young male volunteers 4 days after a single i.m. injection of 10 mg sustained release oestradiol, and it had returned to the starting value 4 weeks after drug administration. Mean plasma oestradiol was 331 pg/ml on Day 4 and it was within the pre-treatment control range of 19 pg/ml 4 weeks after the injection.
A close correlation between the post-injection plasma oestradiol concentration and the increase in alpha2-adrenoceptor binding sites on intact platelets was not found.
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Reimann, I.W., Britzelmeier, C., Haber, P. et al. Influence of oestradiol on alpha2-adrenoceptor binding sites on intact platelets of young male volunteers. Eur J Clin Pharmacol 33, 147–150 (1987). https://doi.org/10.1007/BF00544558
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DOI: https://doi.org/10.1007/BF00544558