Abstract
The following review discusses major directions in the research and preparation of various classes of advanced antitumor agents: synthetic materials which work by an alkylating mechanism (derivatives of di (2-chloroethyl)amine, ethylenimine, alkylnitrosourea, dimethyltriazines); platinum derivatives; dispiropiperazines; alkylating agents derived from polyols; various antimetabolites; as well as compounds derived from natural products, such as anthracycline antibiotics, bleomycin, actinomycin, mitomycin, derivatives of aureolic acid, etc. Also discussed are the use of enzymes to destroy substances needed for tumor growth; new plant alkaloids which inhibit mitosis (Vinca alkaloids, Podophyllin toxins, colchamine, etc.); and immunomodulating agents.
Similar content being viewed by others
Literature cited
N. N. Blokhina (editor), Chemotherapy of Malignant Tumors [in Russian], Meditsina, Moscow (1977).
Z. P. Sof'inoi, A. B. Syrkina, A. Goldina, and A. Klyaina (editors), Experimental Evaluation of Antitumor Drugs in the USSR and USA [in Russian], Meditsina, Moscow (1980).
L. B. Gorbacheva, V. A. Gor'kov, V. A. Chernov, and O. K. Shiyataya, in: Progress in Science and Technology. Oncology [in Russian], VINITI, Vol. 12 (1982), p. 1.
M. N. Preobrazhenskaya and S. Ya. Mel'nik, in: Progress in Science and Technology, Bioorganic Chemistry [in Russian], VINITI, Vol. 1 (1984), p. 1.
A. Sartorelli and D. Johns (editors), Antineoplastic and Immunosuppressive Agents, Vol. 2, Springer-Verlag, Berlin-Heidelberg-New York (1975), p. 1.
J. S. Driscoll, Cancer Treat. Rep., 68, 173 (1984).
U. Ross, Biological Alkylating Agents [in Russian], Meditsina, Moscow (1964).
T. S. Safanova, Zh. Vses. Khim. Ova, 18, 657 (1973).
A. Gilman and F. Philips, Science, 103, 409 (1946).
A. Begleiter, H. Lam, and J. Grover, J. Cancer Res., 39, 353 (1979).
G. Goldenberg, C. Vanston, and I. Bihler, Science, 172, 1148 (1971).
N. M. Émanuél', D. B. Korman, L.P. Ostrovskaya, L. B. Gorbacheva, and N.P. Dement'eva, Nitrasoalkylureas — A New Class of Antitumor Drugs [in Russian], Nauka, Moscow (1978).
L. B. Gorbacheva and G. V. Kukushkina, Eksp. Onkol., 3, 21 (1981).
V. I. Mukhanov, I. L. Kustova, V. N. Gagloev, I. V. Yartseva, V. E. Shevchenko, A. Ya. Veveris, B. A. Spintse, and M. N. Preobrazhenskaya, Bioorg. Khim., 10, 1674 (1984).
A. Johnston, G. McCaleb, W. Rose, and J. Montgomery, J. Med. Chem., 27, 97 (1984).
A. W. Prestayko, L. H. Baker, S. T. Crooke, S. K. Carterm and P. S. Schein (editors), Nitrosoureas: Current Status and New Developments, Academic Press, New York (1981), p. 1.
B. Serrou, P. S. Schein, and J.-L. Imbach (editors), Nitrosoureas in Cancer Treatment, Elsevier/North Holland, Amsterdam (1981), p. 1.
V. Oliviero, in: Cancer Medicine, J. F. Holland and E. Frei, Lea and Febiger, Philadelphia (1973), p. 806.
M. A. Presnov, A. L. Konovalova, and V. P. Korol'chuk, Vestn. Akad. Med. Nauk SSSR, 2, 68 (1979).
A. A. Zidermane, Fluoropyrimidines in Cancer Chemotherapy [in Russian], Zinatne, Riga (1982).
R. K. Robins, P. C. Srivastava, V. L. Narayanan, J. Plowman, and K. D. Paull, J. Med. Chem., 25, 107 (1982).
W. Ensminger, G. Grindey, and J. Hogland, Adv. Cancer Treat. Chemother., 1, 61 (1979).
G. Curt, N. Clendeninn, and B. A. Chabner, Cancer Treat. Rep., 68, 193 (1984).
L. S. Pavarov, Antibiotiki, 22, 653 (1977).
H. Umezawa, Cancer Treat. Rep., 68, 137 (1984).
L. V. Egorov, L. P. Ivanitskaya, and S. M. Navashin, Antibiotiki, 27, 540 (1982).
V. A. Zemkova, M. S. Yurina, and N. N. Lomakina, Antibiotiki, 24, 175 (1979).
Yu. A. Berlin, S. E. Esipov, M. N. Kolosov, and O. A. Chuprunova, Khim. Geterotsikl. Soedin., No. 4, 561 (1969).
S. E. Esipov, M. N. Kolosov, and L. A. Saburova, Antibiotics, 26, 537 (1973).
Abstracts of Proceedings of the Fifth All-Soviet Symposium on Research Goals for Physiologically Active Substances [in Russian], Zinatne, Riga (1983).
R. Oldham, Cancer Treat. Rep., 68, 221 (1984).
Author information
Authors and Affiliations
Additional information
Dedicated to the memory of S. A. Giller, researcher and leader blessed with an unusually keen sense for new challenges.
Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 1, pp. 18–31, January, 1985.
Rights and permissions
About this article
Cite this article
Preobrazhenskaya, M.N. Developments in the research of new antitumor agents (review). Chem Heterocycl Compd 21, 13–24 (1985). https://doi.org/10.1007/BF00505892
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00505892