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Morphine-induced running and analgesia in two strains of mice following septal lesions or modification of brain amines

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Summary

Groups of two inbred strains of mice (C 57 Bl/6J and DBA/2J) with septal and control lesions were tested for morphine-induced analgesia and running activity (running fit). As previously observed the effects of morphine on the running fit and analgesia were strain-dependent and a negative strain correlation was evident between the two measures in C 57 and DBA operated control mice which are characterized by different brain levels and turnover of cholinergic and adrenergic mediators. Septal lesions, which cause a reduction in the levels of acetylcholine, in the brain areas which receive a cholinergic input from the septum, antagonized morphine analgesia in both strains while the running fit syndrome was unaffected. Pharmacological manipulation of brain catecholamines did not interfere with morphineinduced analgesia. The effects of different pharmacological agents which interfere with noradrenaline synthesis and catecholamine oxidation were assessed in the two strains which are characterized by presence (C57) or absence (DBA) of increased motor activity following the injection of morphine. The results argue against an exclusive association of morphine-induced motor activity with noradrenergic mechanism.

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Authors and Affiliations

  1. Laboratorio di Psicobiologia e Psicofarmacologia, Via Reno 1, I-00198, Roma, Italy

    Claudio Castellano, Blai Espinet Llovera & Alberto Oliverio

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  1. Claudio Castellano
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  2. Blai Espinet Llovera
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  3. Alberto Oliverio
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This work was supported by an Italian and French National Research Council Research grant and from an European Training Program Brain and Behaviour Research grant.

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Castellano, C., Llovera, B.E. & Oliverio, A. Morphine-induced running and analgesia in two strains of mice following septal lesions or modification of brain amines. Naunyn-Schmiedeberg's Arch. Pharmacol. 288, 355–370 (1975). https://doi.org/10.1007/BF00501282

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  • DOI: https://doi.org/10.1007/BF00501282

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