Summary
Treatment with aminooxyacetic acid (AOAA, 50 mg/kg i.p.) did not significantly change the concentrations of dopamine and noradrenaline in the rat brain. It markedly and similarly decelerated the disappearance of dopamine in the corpus striatum and the limbic system after treatment with dl-α-methytyrosine methylester (α-MT, 250 mg/kg i.p., 4 h) and accelerated the disappearance of noradrenaline. It also blocked the acceleration of the α-MT-induced dopamine, but not noradrenaline, disappearance caused by haloperidol. Administration of gamma-hydroxybutyric acid (GHBA, 1.5+1.0 g/kg i.p.) resulted in a larger retardation of the α-MT-induced dopamine disappearance which was about the same in the corpus striatum and the limbic system. Treatment with GHBA also increased the endogenous dopamine and this effect was significantly larger in the corpus striatum than in the limbic system like after an axotomy. The effect of AOAA may be due to accumulation of GABA inhibiting the cell bodies of the dopaminergic neurones.
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References
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Andén, NE. Inhibition of the turnover of the brain dopamine after treatment with the gammaaminobutyrate: 2-oxyglutarate transaminase inhibitor aminooxyacetic acid. Naunyn-Schmiedeberg's Arch. Pharmacol. 283, 419–424 (1974). https://doi.org/10.1007/BF00501114
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DOI: https://doi.org/10.1007/BF00501114