Summary
Factors governing the development of apomorphine-induced biphasic circling behaviour in rats having unilateral 6-hydroxydopamine lesions of the substantia nigra were investigated. It was found that a post-lesion time of at least 2–3 weeks and the repeated exposure to apomorphine were essential for its development. Optimal results were obtained when animals received weekly apomorphine, 0.05 mg/kg sc, in post-lesion weeks 6, 7 and 8. Pretreatment with haloperidol, 1.0 and 2.0 mg/kg ip 1 h beforehand in post-lesion week 9, converted the biphasic response into an enhanced, uniphasic one.
The findings suggest that the development of the biphasic response to apomorphine is a multi-factorial process representing a pharmacological kindling phenomenon.
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Coward, D.M. Apomorphine-induced biphasic circling behaviour in 6-hydroxydopamine-lesioned rats. Naunyn-Schmiedeberg's Arch. Pharmacol. 323, 49–53 (1983). https://doi.org/10.1007/BF00498827
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DOI: https://doi.org/10.1007/BF00498827