Summary
Mature juxtaglomerular epithelioid cell secretory granules of the rat exhibit both renin- and cathepsin B-like immunoreactivity. On the basis of the coexistence with renin at a pH which, according to previous experiments, is probably in the range of that in lysosomes, cathepsin B is suggested to be involved in the activation of renin prior to secretion.
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These studies were supported by the German Research Foundation within the SFB 90 “Cardiovasculäres System”
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Taugner, R., Bührle, C.P., Nobiling, R. et al. Coexistence of renin and cathepsin B in epithelioid cell secretory granules. Histochemistry 83, 103–108 (1985). https://doi.org/10.1007/BF00495138
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DOI: https://doi.org/10.1007/BF00495138