Abstract
The selenium concentration of serum is age-dependent. The median value at birth (\(\tilde x\)=50×10−9g/ml) amounts to half of the median value of adults (\(\tilde x\)=102×10−9g/ml). After a decrease in early infancy to \(\tilde x\)=34×10−9g/ml it steadily increases to \(\tilde x\)=58×10−9g/ml in the second half of the first year, to \(\tilde x\)=82×10−9g/ml in 1–5 year old children, and to \(\tilde x\)=92×10−9g/ml in school children. The activities of the selenium containing enzyme glutathione peroxidase of erythrocytes are also reduced in early infancy (x=7.2±0.36 U37/g Hb), whereas the enzyme activities of cord blood erythrocytes (x=8.72±0.76 U37/g Hb) are in the same range as those of older children or adults. The selenium content of some commercially available milk formulas for infants are lower than those of human and cow's milk.
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Allaway, W. H., Cary, E. F., Ehlig, C. F.: The cycling of low levels of selenium in soils, plants and animals. In: Selenium in Biomedicine. Eds.: Muth, O. H., Oldfield, J. E. and Weswig, P. H. The Avi Publ. Co., Inc., Westport, Conn., pp. 273–296 (1967)
Beutler, E., Srivastava, S. K.: The role of glutathione in the lens. Hoppe-Seyler's Z. Physiol. Chem. 354, 834 (1973)
Bracci, R.: Il deficit di glutatione-perossidase eritrocitaria nel neonato con malattia emolitica. Minerva Pediatrica 20, 2692–2695 (1968)
Burk, R. F., Pearson, W. N., Wood, R. P., Viteri, F.: Blood selenium levels and in vitro red blood cell uptake of 75-Se in Kwashiorkor. Amer. J. Clin. Nutr. 20, 723–733 (1967)
Cadell, P. B., Cousins, F. B.: Urinary selenium and dental caries. Nature 185, 863–864 (1960)
Cooper, W. C., Glover, J. R.: The toxicology of selenium and its compounds. In: Selenium, pp. 654–674. Eds.: Zingaro, R. A., Cooper, W. C.. New York, Cincinnati, Toronto, London, Melbourne: van Nostrand Reinhold Co. 1974
Dickson, R. C., Tomlinson, R. H.: Selenium in blood and human tissues. Clin. Chim. Acta 16, 311–321 (1967)
Diplock, A. T., Green, J., Bunyan, J., Mc Hale, D., Muthy, J. R.: Vitamin E and stress. 3. the metabolism of D-α-tocopherol in the rat under dietary stress with silver. Brit. J. Nutr. 1, 115–125 (1967)
Diplock, A. T.: The nutritional and metabolic roles of selenium and vitamin E. Proc. Nutr. 33, 315–322 (1974)
Emerson, P. U., Mason, D. Y., Cuthbert, J. E.: Erythrocyte glutathione peroxidase content and serum tocopherol levels in newborn infants. Brit. J. Haematol. 22, 667–680 (1972)
Flohé, L., Günzler, W. A., Schock, H. H.: Glutathione peroxidase: A selenoenzyme. FEBS Letters 32, 132–134 (1973)
Glader, B. E., Conrad, M. E.: Decreased glutathione peroxidase in neonatal erythrocytes: Lack of relation to hydrogen peroxide metabolism. Pediat. Res. 6, 900–904 (1972)
Griffiths, N. M., Thomson, Ch. D.: Selenium in whole blood of New Zealand residents. New Z. J. Med. 80, 199–202 (1974)
Gross, R. T., Bracci, R., Rudolph, N., Schroeder, E., Kochen, J. A.: Hydrogen peroxide toxicity and detoxification in the erythrocytes of new born infants. Blood 29, 481–493 (1967)
Günzler, W. A., Kremers, H., Flohé, L.: An improved coupled test procedure for glutathione peroxidase in blood. z. Klin. Chem. Klin. Biochem. 12, 444–448 (1974)
Hadjimarkos, D. M.: Effect of selenium on dental caries. Arch. Environ. Health 10, 893–899 (1965)
Hartley, W. J., Grant, A. B.: A review of selenium responsive diseases at New Zealand livestock. Fed. Proc. 20, 679–688 (1961)
Higgs, D. J., Morris, V. C., Levander, O. A.: Effect of cooking on selenium content of foods. J. Agr. Food Chem. 20, 678–680 (1972)
Hill, C. H.: Reversal of selenium toxicity in chicks by mercury, copper and cadmium. J. Nutr. 104, 593–598 (1974)
Kasperek, K.: Analytical techniques for the determination of 20 trace elements in biological samples by means of instrumental thermal neutron activation analysis. In: Proc. of the 2nd internat. conf. on nuclear methods in environmental research, U.S. Energy research and development administration, Conf. 740 701, 1974
Kiermeyer, F., Wigand, W.: Selengehalt von Milch und Milchpulver. Z. Lebensmitt. unters. 139, 205–211 (1968)
Levine, R. J., Olson, R. E.: Blood selenium in Thai children with protein-caloric malnutrition. Proc. Soc. Expt. Biol. Med. 134, 1030–1034 (1970)
Morris, V. C., Levander, O. A.: Selenium content of foods. J. Nutr. 100, 1383–1388 (1970)
Muth, O. H., Weswig, P. H., Whanger, P., Oldfield, J. E.: Effect of feeding selenium-deficient ration to the subhuman primate. Amer. J. Res. 32, 1603–1605 (1971)
Necheles, T. F., Steinberg, M. H., Cameron, D.: Erythrocyte glutathione-peroxidase deficiency. Brit. J. Haematol. 19, 605–612 (1970)
Noguchi, R., Cantor, A. H., Scott, M. L.: Mode of action of selenium and vitamin E in prevention of exudative diathesis in chicks. J. Nutr. 103, 1502–1511 (1973)
Paglia, D. E., Valentine, W. N.: Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70, 158–169 (1967)
Rosenfeld, I., Beath, O. A.: Accumulation of selenium by plants. In: Selenium Gebotany, Biochemistry, Toxicity and Nutrition, pp. 91–140. New York and London: Acad. Press 1964
Rotruck, J. T., Pope, A. L., Ganther, H. E., Swanson, A. B., Hafeman, D. G., Hoekstra, W. G.: Selenium: Biochemical role as a component of glutathione peroxidase. Science 179, 588–590 (1973)
Sakurai, H., Tsuchiya, K.: A tentative recommendation for the maximum daily intake of selenium. Environ. Physiol. Biochem. 5, 107–118 (1975)
Schwarz, K., Foltz, C. M.:Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J. Amer. Chem. Soc. 79, 3292 (1957)
Schwarz, K.: Development and status of experimental work and factor 3-selenium. Fed. Proc. 20, 666–673 (1961)
Schwarz, K.: Selenium and Kwashiorkor. Lancet 1965I, 1335–1336
Shamberger, R. J., Frost, D. V.: Possible protective effect of selenium against human cancer. Can. Med. Ass. J. 100, 682 (1969)
Shearer, T. R., Hadjimarkos, D. M.: Geographic distribution of selenium in human milk. Arch. Environ. Health 30, 230–233 (1975)
Thompson, J. N., Erdy, P., Smith, D. C.: Selenium content of food consumed by Canadians. J. Nutr. 105, 274–277 (1975)
Vetrella, M., Barthelmai, W., Rietkötter, J.: Aktivität der Glutathion-Peroxidase in Erythrocyten vom Fetal- bis zum Erwachsenenalter. Klin. Wschr. 48, 85–88 (1970)
Watkinson, J. H.: The selenium status of New Zealanders. N. Z. Med. J. 523, 202–205 (1974)
Whanger, P. D., Pedersen, N. D., Weswig, P. H.: Selenium proteins in ovine tissues, II. Spectral properties of a 10 000 molecular weight selenium protein. Biochem. Biophys. Res. Commun. 53, 1031–1035 (1973)
Whaun, J. M., Oski, F. A.: Relation of red blood cell glutathione peroxidase to neonatal jaundice. J. Pediat. 76, 555–560 (1970)
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Lombeck, I., Kasperek, K., Harbisch, H.D. et al. The selenium state of healthy children. Eur J Pediatr 125, 81–88 (1977). https://doi.org/10.1007/BF00470608
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DOI: https://doi.org/10.1007/BF00470608