Abstract
The benzene ring of indoles was amidomethylated by various agents in the presence of sulfuric acid. The amidomethylation of 2-methyl- and 2,3-dimethylindoles takes place in the 5 position. When there is a methyl or methoxy group in the 5 or 7 position, the substituent enters the 6 position. Hydrazinolysis or hydrolysis of the amidomethylation products gives 5- or 6-aminomethylindoles.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1066–1069, August, 1978.
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Yudin, L.G., Abdullaev, M. & Kost, A.N. Amidomethylation of the benzene ring of indoles. Chem Heterocycl Compd 14, 856–859 (1978). https://doi.org/10.1007/BF00469862
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DOI: https://doi.org/10.1007/BF00469862