Summary
Transtympanic administration of gentamicin was used to treat patients with unilateral Menière's disease and was stopped at the first signs of damage to cochlear and/or vestibular function. Twenty-eight patients were treated between 1974 and 1981 and 34 patients were managed between 1981 and 1987. In the two groups of patients, objective vertigo disappeared in 85%, hearing improved in 26%, aural fullness disappeared in 78%, while tinnitus ceased altogether in 51% and became less intense in 24%. Our findings show that this kind of treatment can be used after unsuccessful medical therapy and prior to any labyrinthine or endolymphatic sac surgery.
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Sala, T. Transtympanic administration of aminoglycosides in patients with Menière's disease. Arch Otorhinolaryngol 245, 293–296 (1988). https://doi.org/10.1007/BF00464634
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DOI: https://doi.org/10.1007/BF00464634