Zusammenfassung
Die Untersuchung der Wirkung von Betahistin, einem Medikament zur Beeinflussung des Schwindels, auf den Nucleus vestibularis lateralis der Katze, zeigte eine Erregungshemmung der polysynaptischen Neurone, während die Reaktion der monosynaptischen unbeeinflußt blieb.
Summary
Effects of betahistine, an antivertigo drug, were examined on the lateral vestibular nucleus (LVN) neurons of cats anesthetized with α-chloralose. Spike generation of monosynaptic LVN neurons elicited by vestibular nerve stimulation remained unaffected with intravenous administration of betahistine up to 5 mg/kg and with iontophoretic application of the drug up to 200 nA. In contrast, the spike generation of polysynaptic I neurons in the LVN was dose-dependently inhibited by intravenous as well as iontophoretic application of betahistine. These results suggest that small doses of betahistine more selectively interfere with synaptic transmission in the polysynaptic I neurons than in the monosynaptic neurons.
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Unemoto, H., Sasa, M., Takaori, S. et al. Inhibitory effect of betahistine on polysynaptic neurons in the lateral vestibular nucleus. Arch Otorhinolaryngol 236, 229–236 (1982). https://doi.org/10.1007/BF00454214
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DOI: https://doi.org/10.1007/BF00454214