Abstract
The molecular polymorphism and quantitative data of serum transferrin (Tf) were ascertained in a group of fibrocystic patients, their parents and controls. Quantitative rates of pre-albumin, retinol binding globulin (RBG) and alpha-1-glycoprotein were also investigated as a reference for the evaluation of Tf quantitative data.
Neither different allele distributions nor abnormal electrophoretic patterns were observed among CF patients.
A slight lowering of Tf, pre-albumin and RBG, probably due to malnutritional condition in CF subjects was found.
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Abbreviations
- Tf:
-
serum transferrin
- RBG:
-
retinol binding globulin
- CF:
-
cystic fibrosis
References
Alhadeff AJ (1978) Glycoproteins and cystic fibrosis: a review. Clin Genet 14:189–201
Alhadeff JA, Cimino G (1978) Cystic fibrosis sialyltransferase. Clin Genet 13:207–212
Bowman BH, Barnett DR, Coppenhaver D (1981) A transferrin variant in a kindred with cystic fibrosis. Hum Hered 31:248–251
Coppenhaver D, Kueppers F, Schidlow D, Bee D, Isenburg JN, Barnett DR, Bowman BH (1981) Serum concentrations of vitamin D-binding protein (group-specific component) in cystic fibrosis. Hum Genet 57:399–403
Dische DP, Di Sant'Agnese P, Pallavicini C, Youlous J (1959) Composition of mucoprotein fraction from duodenal fluid of patients with cystic fibrosis of the pancreas and from controls. Pediatrics 24:74–91
Housley TJ, Rowland FN, Ledger PW, Kaplam J, Tanzer JL (1980) Effects of tunicamycin in the biosynthesis of tropocollagen by human fibroblast. J Biol Chem 255:121–128
Ingenbleek Y, Visscher M, De Nayer PH (1972) Measurement of pre-albumin as an index of protein-calorie malnutrition. Lancet II:106–109
Pascali VL, Ranalletta D, Auconi P (1982) Improved typing of human serum transferrin by isoelectric focusing on ultrathin-layer polyacrylamide slab gels. Hum Genet 61:39–41
Pearson RD, Lubin AH (1977) Increased heparin glycoproteins synthesis. Pediatr Res 11:462 (Abstr)
Shwachman H (1975) Gastrointestinal manifestations of cystic fibrosis. Pediatr Clin North Am 22:787–805
Shwachman H (1981) Nutritional considerations in the treatment of children with the cystic fibrosis. In: Suskind RM (ed) Textbook of pediatric nutrition. Raven Press, New York, pp 511–525
Underwood BA, Denning CR (1971) Correlation between plasma and liver concentrations of vitamin A and E in children with cystic fibrosis. Bull NY Acad Med 47:34–39
Wilson GB, Fudenberg HH (1975) Studies on cystic fibrosis using isoelectric focusing. I. An assay for detection of cystic fibrosis homozygotes and heterozygote carriers from serum. Pediatr Res 9:635–640
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Pascali, V.L., Bravo, E., Auconi, P. et al. Transferrin subtypes in cystic fibrosis. Eur J Pediatr 143, 133–134 (1984). https://doi.org/10.1007/BF00445801
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DOI: https://doi.org/10.1007/BF00445801