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Oral bacteriotherapy in clinical practice

I. The use of different preparations in infants treated with antibiotics

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Abstract

Twenty-seven reference subjects without any therapy, 17 with oral Ampicillin therapy and 33 with oral Ampicillin therapy plus different commercially available preparations of oral bacteriotherapy were studied clinically and their faeces analysed microbiologically. No cases of pseudomembranous colitis were observed; the majority of infants with only Ampicillin therapy showed a moderate increase in stool frequency. Oral bacteriotherapy given in high dosages and with definite characteristics reduces stool frequency during antibiotic therapy. It inhibits the lowering of faecal flora induced by Ampicillin and restablishes the equilibrium of the intestinal ecosystem, thus preventing excessive growth of organisms already present and/or superinfection with antibiotic-resistant flora.

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References

  1. Bartlett JG (1979) Antibiotic associated colitis. Clin Gastroenterology 8:783–801

    Google Scholar 

  2. Beerens H, Romond C, Neut C (1980) Influence of breast-feeding on the bifid flora of the newborn intestine. Am J Clin Nutr 33:2434–2439

    Google Scholar 

  3. Bertazzoni E, Velo GP, Vettori G, Berti T (1968) Antibacterial activity of rifampicin on faecal flora in the rat. Antibiotica 6:1–9

    Google Scholar 

  4. Berti T, Scuka M (1967) Qualitative and quantitative effect of chemotherapeutics and antibiotics on the intestinal flora of the rat. 5th Int Congr Chemotherapy, Wien, Suppl, p 567

  5. Bourrillon A, Lambert-Zechovsky N, Beaufils F, Lejeune C, Binghen E, Blum C, Mathieu H (1978) Antibiotherapie et pullulation microbienne intestinale et risque infectieux chez l'enfant. Arch Franç Pédiat 35:2337

    Google Scholar 

  6. Bullen CL, Willis AT (1971) Resistance of the breast-fed infant to gastroenteritis. Brit Med J 3:338–342

    Google Scholar 

  7. Conn HO, Floch MH (1970) Effects of lactulose and lactobacillus acidophilus on the fecal flora. Am J Clin Nutr 23:1588–1594

    Google Scholar 

  8. Drasar BS, Hill MS (1974) Human intestinal flora. Academic Press, London, pp 25–35

    Google Scholar 

  9. Fekety R, Keem KH, Batts DH, Browne RA, Cudmore MA, Silva J Jr, Toshniwal R, Wilson KN (1980) Studies on the epidemiology of antibiotic-associated Clostridium difficile colitis. Am J Clin Nutr 33:2527–2532

    Google Scholar 

  10. George WL, Rolfe RD, Sutter VL, Finegold SM (1979) Diarrhoea and colitis associated with antimicrobiol therapy in man and animals. Am J Clin Nutr 32:251–258

    Google Scholar 

  11. Gorbach SL (1971) Intestinal microflora. Gastroenterology 68:1110–1128

    Google Scholar 

  12. Gordon D, Macrae J, Wheater DM (1957) A lactobacillus preparation for use with antibiotics. Lancet 1:899–901

    Google Scholar 

  13. Gurwith MJ, Rabin HR, Love K, and Study Group (1977) Diarrhoea associated with clindamycin and ampicillin therapy: preliminary results of a cooperative study. J Infect Dis 135:S104-S110

    Google Scholar 

  14. Hoffman AF (1978) Bile acids, diarrhoea and antibiotics. Data, speculation and a unifying hypothesis. J Infect Dis 135:S126-S132

    Google Scholar 

  15. Metchnikoff E (1908) Prolongation of life. GP Putnams Sons, New York

    Google Scholar 

  16. Miller RR, Jick H (1977) Antibiotic associated colitis. Clin Pharm Therap 22:1–5

    Google Scholar 

  17. Minelli Bertazzoni E, Benoni G, Berti T, Deganello A, Zoppi G, Gaburro D (1977) A simplified method for the evaluation of human faecal flora in clinical practice. Helv Paediat Acta 32:471–478

    Google Scholar 

  18. Paul D, Hoskins LC (1972) Effect of oral lactobacillus feeding on fecal lactobacillus counts. Am J Clin Nutr 25:763–765

    Google Scholar 

  19. Shahani KM, Ayebo AD (1980) Role of dietary lactobacilli in gastrointestinal microecology. Am J Clin Nutr 33:2448–2457

    Google Scholar 

  20. Weijers HA, Van de Kamer JH (1965) Alteration of intestinal bacterial flora as a cause of diarrhoea. Nutr Abstr Rev 35:591–604

    Google Scholar 

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Zoppi, G., Deganello, A., Benoni, G. et al. Oral bacteriotherapy in clinical practice. Eur J Pediatr 139, 18–21 (1982). https://doi.org/10.1007/BF00442072

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  • DOI: https://doi.org/10.1007/BF00442072

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