Abstract
Twenty-seven reference subjects without any therapy, 17 with oral Ampicillin therapy and 33 with oral Ampicillin therapy plus different commercially available preparations of oral bacteriotherapy were studied clinically and their faeces analysed microbiologically. No cases of pseudomembranous colitis were observed; the majority of infants with only Ampicillin therapy showed a moderate increase in stool frequency. Oral bacteriotherapy given in high dosages and with definite characteristics reduces stool frequency during antibiotic therapy. It inhibits the lowering of faecal flora induced by Ampicillin and restablishes the equilibrium of the intestinal ecosystem, thus preventing excessive growth of organisms already present and/or superinfection with antibiotic-resistant flora.
Similar content being viewed by others
References
Bartlett JG (1979) Antibiotic associated colitis. Clin Gastroenterology 8:783–801
Beerens H, Romond C, Neut C (1980) Influence of breast-feeding on the bifid flora of the newborn intestine. Am J Clin Nutr 33:2434–2439
Bertazzoni E, Velo GP, Vettori G, Berti T (1968) Antibacterial activity of rifampicin on faecal flora in the rat. Antibiotica 6:1–9
Berti T, Scuka M (1967) Qualitative and quantitative effect of chemotherapeutics and antibiotics on the intestinal flora of the rat. 5th Int Congr Chemotherapy, Wien, Suppl, p 567
Bourrillon A, Lambert-Zechovsky N, Beaufils F, Lejeune C, Binghen E, Blum C, Mathieu H (1978) Antibiotherapie et pullulation microbienne intestinale et risque infectieux chez l'enfant. Arch Franç Pédiat 35:2337
Bullen CL, Willis AT (1971) Resistance of the breast-fed infant to gastroenteritis. Brit Med J 3:338–342
Conn HO, Floch MH (1970) Effects of lactulose and lactobacillus acidophilus on the fecal flora. Am J Clin Nutr 23:1588–1594
Drasar BS, Hill MS (1974) Human intestinal flora. Academic Press, London, pp 25–35
Fekety R, Keem KH, Batts DH, Browne RA, Cudmore MA, Silva J Jr, Toshniwal R, Wilson KN (1980) Studies on the epidemiology of antibiotic-associated Clostridium difficile colitis. Am J Clin Nutr 33:2527–2532
George WL, Rolfe RD, Sutter VL, Finegold SM (1979) Diarrhoea and colitis associated with antimicrobiol therapy in man and animals. Am J Clin Nutr 32:251–258
Gorbach SL (1971) Intestinal microflora. Gastroenterology 68:1110–1128
Gordon D, Macrae J, Wheater DM (1957) A lactobacillus preparation for use with antibiotics. Lancet 1:899–901
Gurwith MJ, Rabin HR, Love K, and Study Group (1977) Diarrhoea associated with clindamycin and ampicillin therapy: preliminary results of a cooperative study. J Infect Dis 135:S104-S110
Hoffman AF (1978) Bile acids, diarrhoea and antibiotics. Data, speculation and a unifying hypothesis. J Infect Dis 135:S126-S132
Metchnikoff E (1908) Prolongation of life. GP Putnams Sons, New York
Miller RR, Jick H (1977) Antibiotic associated colitis. Clin Pharm Therap 22:1–5
Minelli Bertazzoni E, Benoni G, Berti T, Deganello A, Zoppi G, Gaburro D (1977) A simplified method for the evaluation of human faecal flora in clinical practice. Helv Paediat Acta 32:471–478
Paul D, Hoskins LC (1972) Effect of oral lactobacillus feeding on fecal lactobacillus counts. Am J Clin Nutr 25:763–765
Shahani KM, Ayebo AD (1980) Role of dietary lactobacilli in gastrointestinal microecology. Am J Clin Nutr 33:2448–2457
Weijers HA, Van de Kamer JH (1965) Alteration of intestinal bacterial flora as a cause of diarrhoea. Nutr Abstr Rev 35:591–604
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zoppi, G., Deganello, A., Benoni, G. et al. Oral bacteriotherapy in clinical practice. Eur J Pediatr 139, 18–21 (1982). https://doi.org/10.1007/BF00442072
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00442072