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Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis

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Abstract

Thyroid function and serum TSI levels in two siblings with neonatal thyrotoxicosis are described. The first infant was treated with exchange transfusion and potassium iodide. The second infant was treated with intrauterine propylthiouracil followed by potassium iodide. In contrast to the first infant, the second infant had no clinical sign of neonatal thyrotoxicosis. He also had lower TSI levels with a biological halflife of 5 days. Only one of three assays showed some TSI activity in breast milk.

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Abbreviations

TSI:

thyroid-stimulating immunoglobulins

LATS:

long-acting thyroid stimulator

LATS-P:

LATS protector

TSAb:

thyroid-stimulating antibody

TRAB:

TSH receptor antibodies

PTU:

propylthiouracil

TBG:

thyroxinbinding globulin

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Authors and Affiliations

  1. Het Wilhelmina Kinderziekenhuis, Nieuwe Gracht 137, 3512 LK, Utrecht, The Netherlands

    J. M. Wit

  2. Endocrine Immunology Unit, University of Wales, College of Medicine, 7th Floor Medicine, Cardiff, UK

    B. Rees-Smith & F. M. Creagh

  3. Department of Obstetrics and Gynaecology, State University Hospital, Utrecht, The Netherlands

    H. W. Bruinse

  4. Department of Endocrinology and Metabolic Diseases, University Hospital Leiden, The Netherlands

    D. van der Heide

  5. Department of Endocrinology and Metabolic Diseases, Academic Hospital, Rotterdam, The Netherlands

    R. Docter

  6. Department of Neonatology, University Hospital for Children and Youth “Het Wilhelmina Kinderziekenhuis”, Utrecht, The Netherlands

    L. J. Gerards

Authors
  1. J. M. Wit
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  2. B. Rees-Smith
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  3. F. M. Creagh
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  4. H. W. Bruinse
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  5. D. van der Heide
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  6. R. Docter
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  7. L. J. Gerards
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Wit, J.M., Rees-Smith, B., Creagh, F.M. et al. Thyroid-stimulating immunoglobulins and thyroid function tests in two siblings with neonatal thyrotoxicosis. Eur J Pediatr 145, 143–147 (1986). https://doi.org/10.1007/BF00441879

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  • DOI: https://doi.org/10.1007/BF00441879

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