Summary
A dramatic reduction in the total number of dense vesicles in Auerbach's plexus of the mouse colon was observed during the acute phase of experimental American Trypanosomiasis (Chagas' disease). A significant decrease in substance P activity of the colon of inoculated animals was also measured. It is suggested that this decrease in substance P activity could be related to the reduction in the number of dense vesicles in Auerbach's plexus.
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Baumgarten, H.G.: über die Verteilung von Catecholaminen im Darm des Menschen. Z. Zellforsch. 83, 133–146 (1967)
Douglas, W.W., Feldberg, W., Paton, W.D.M., Schachter, M.: Distribution of histamine and substance P in the wall of the dog's digestive tract. J. Physiol. (Lond.) 115, 163–176 (1951)
Fisher, G.H., Humphries, J., Folkers, K., Pernow, B., Bowers, C.Y.: Synthesis and biological activities of Substance P. J. Med. Chem. 17, 843–846 (1974)
Grillo, M., Pallay, S.L.: Granule containing vesicles of the autonomic nervous system. In: Procedings of the 5th International Congress of the Electron Microscopy (Breese, S.S., ed.) vol. 2, U-1. New York: Academic Press 1962
Hager, H., Tafuri, W.L.: Elektronenoptische Nachweise sogenannter neurosekretorischer Elementargranular in marklosen Nervenfasern des plexus myentericus (Auerbach) des Meerschweinchens. Naturwissenschaften 46, 333–334 (1959)
Hial, V., Diniz, C.R., Pittella, J.E.H., Tafuri, W.L.: Quantitative study of P substance in the megaesophagus and megacolon of human Trypanosoma cruzi infections. J. Trop. Med. Hyg. 76, 175–179 (1973)
Machado, A.B.M., Machado, C.R.S., Gomes, C.B.: Depletion of heart norepinephrine in experimental acute myocarditis caused by Trypanosoma cruzi. Experientia 31, 1202–1203 (1975)
Nilson, G., Larsson, L.I., Hakanson, R., Brodin, E., Pernow, B., Sundler, F.: Localization of substance P like immunoreactivity in mouse gut. Histochemistry 43, 97–99 (1975)
Pernow, B.: Studies on substance P — purification, occurence and biological actions. Acta physiol. scand. 29, suppl. 105 (1953)
Silva, L.H.P., Nussenzweig, V.: Sobre uma cepa de Trypanosoma cruzi altamente virulenta para o camundongo branco. Folia clin. et biol. 20, 191–207 (1953)
Tafuri, W.L.: Ultrastructure of vesicular component in the intramural nervous system of the guineapig's intestine. Z. Naturforsch. 19b, 622–625 (1964)
Tafuri, W.L.: Microscopia electrÔnica do colo do camundongo na fase aguda da tripanossomiase cruzi experimental. Rev. Ass. Med. Minas Gerais 20, 209–220 (1969)
Tafuri, W.L.: Light and electron microscope studies of the autonomic nervous system in experimental and human american trypanosomiasis. Virchows Arch. Abt. A, Path. Anat. 354, 136–149 (1971)
Tafuri, W.L., Maria, T.A., Freire-Maia, L., Cunha-Melo, J.R.: Effect of the scorpion toxin on the granular vesicles in the Auerbach's plexus of the rat ileum. J. Neural Transm. 35, 233–240 (1974a)
Tafuri, W.L., Pittella, J.E.H., Bogliolo, L., Hial, W., Diniz, C.R.: An electron microscope study of the Auerbach's plexus and determination of substance P content of the colon in Hirschsprung's disease. Virchows Arch. A Path. Anat. and Histol. 362, 41–50 (1974b)
Tranzer, J.P., Thoenen, H., Snipes, R., Richards, J.: Recents developments on the ultrastructural aspect of adrenergic nerve endings in various experimental conditions. Progr. Brain Res. 31, 33–46 (1969)
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Almeida, H.O., Tafuri, W.L., Cunha-Melo, J.R. et al. Studies on the vesicular component of the Auerbach's plexus and the substance P content of the mouse colon in the acute phase of the experimental Trypanosoma cruzi infection. Virchows Arch. A Path. Anat. and Histol. 376, 353–360 (1977). https://doi.org/10.1007/BF00432304
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DOI: https://doi.org/10.1007/BF00432304