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Central muscarinic receptors and male rat sexual behavior: Facilitation by oxotremorine but not arecoline or pilocarpine in methscopolamine pretreated animals

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Abstract

Oxotremorine (0.1–0.8 mg/kg IP), but not arecoline (12–48 mg/kg IP), or pilocarpine (5–20 mg/kg IP), reduced both the number of intromissions to ejaculation and the ejaculation latency in methscopolamine-pretreated male rats. The effects of oxotremorine, (0.4 mg/kg IP) were completely antagonized by the administration of scopolamine (0.4 mg/kg IP). Methscopolamine (3–12 mg/kg IP), or scopolamine (0.2–0.4 mg/kg IP) did not by themselves produce any statistically significant effects on male rat sexual behavior.

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Authors and Affiliations

  1. Research and Development Laboratories, Pharmacology, Astra Läkemedel AB, S-151 85, Södertälje, Sweden

    Sven Ahlenius

  2. Department of Psychology, University of Göteborg, Box 14158, S-400 20, Göteborg, Sweden

    Knut Larsson

Authors
  1. Sven Ahlenius
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  2. Knut Larsson
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Ahlenius, S., Larsson, K. Central muscarinic receptors and male rat sexual behavior: Facilitation by oxotremorine but not arecoline or pilocarpine in methscopolamine pretreated animals. Psychopharmacology 87, 127–129 (1985). https://doi.org/10.1007/BF00431794

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  • DOI: https://doi.org/10.1007/BF00431794

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