Summary
Captive baboons of three age groups were experimentally infected with Herpesvirus SA 8-strain 0430.
Intravenous inoculation of the virus induced minor, transient, interstitial pneumonia of a nonspecific type in newborn baboons.
Intratracheal inoculation, in contrast, invariably produced multifocal or diffuse necrotizing inclusion body bronchopneumonia within two days in newborn, two months and one year old baboons. Differences in the outcome of the experimental intratracheal infections were noticed, depending on the animals age. All the newborns either died from the extensive pulmonary damage or had to be sacrificed because of serious illness. Older animals, in contrast, survived the initial impact with only minor clinical symptoms and repair of the necrotic and inflammatory lesions. The healing stages were characterized by interstitial fibrosis and transient tumorlike bronchial and bronchiolar epithelial proliferations, which lasted for approximately two months.
Intranuclear inclusion bodies in ganglionic cells, ganglioneuritis and neuritis in different parts of the pulmonary plexus in intratracheally infected animals suggested the viral invasion of the pulmonary autonomous nervous system.
Zusammenfassung
Paviane dreier Altersklassen wurden experimentell (intravenös, intratracheal) mit Herpesvirus SA 8-Stamm 0430 infiziert.
Intravenöse Injektion löste bei neugeborenen Pavianen geringgradige, vorübergehende, interstitielle Pneumonien ohne spezifische Komponenten aus.
Intratracheale Instillation der Virussuspension führte ungeachtet des Alters der Versuchstiere zu fokalen bis ausgedehnten nekrotisierenden Einschlußkörper-Bronchopneumonien. Aus den schon zwei Tage p.i. ausgebildeten Nekrosen und Entzündungen entwickelten sich im späteren Verlauf der intratrachealen Infektionen interstitielle Fibrosen und vorübergehend tumorähnliche Epithelproliferationen.
Intranucleäre Einschlußkörper in Ganglienzellen, Ganglioneuritis und Neuritis im Bereich des Pulmonalplexus intratracheal infizierter Tiere sprechen für eine Ausbreitung der Infektion auf das autonome Nervensystem der Lunge.
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Mit dankenswerter Unterstützung durch die Deutsche Forschungsgemeinschaft, Bonn-Bad Godesberg-Br 414/1, 2
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Brack, M., Eichberg, J.W., Heberling, R.L. et al. Experimentelle Herpesvirus SA 8-Pneumonien (Bronchopneumonien) bei Kenia-Pavianen (Papio cynocephalus). Virchows Arch. A Path. Anat. and Histol. 392, 81–96 (1981). https://doi.org/10.1007/BF00430551
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DOI: https://doi.org/10.1007/BF00430551