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Modulatory effect of sera from scleroderma patients on lymphocyte-induced angiogenesis. II. Effector cells for the enhancing effect of acroscleroderma patients' sera

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Summary

In our previous study, using the modified lymphocyte-induced angiogenesis assay, we found that incubation of normal human peripheral blood mononuclear cells (PBMCs) with sera from patients with acroscleroderma, but not with diffuse scleroderma, markedly enhanced their angiogenic capability. The results of the present work suggest that this enhancement is mediated by lymphocytes bearing receptors for the Fc portion of IgG and belonging mainly to the CD4+ T-cell subset.

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References

  1. Bentwich Z, Douglas D, Skutelsky E, Kunkel HG (1973) Sheep red cell binding to human lymphocytes treated with neuraminidase: enhancement of T cell binding and identification. J Exp Med 137:1532–1536

    Google Scholar 

  2. Boyum A (1968) Isolation of mononuclear cells and granulocytes from human blood. Scand J Clin Lab Invest 97 [Suppl]:77–89

    Google Scholar 

  3. Chorzelski TP, Jabŀońska S, Beutner EH, Bŀaszczyk M, Jarz abek-Chorzelska M, Kencka D, Krasny S, Kumar V, Tchórzewska A (1985) Anticentromere antibody: an immunological marker of a subset of systemic sclerosis. Br J Dermatol 113:381–389

    Google Scholar 

  4. Fleischmajer R, Perlish JS (1977) 3H-thymidine labeling of dermal endothelial cells in scleroderma. J Invest Dermatol 69:379–382

    Google Scholar 

  5. Froelich CJ, Bankhurst AD, Warner NL (1982) Characterization of E-rosette-positive Fc-receptor bearing cells by flow cytometry. Clin Immunol Immunopathol 22:105–117

    Google Scholar 

  6. Griend RJ, Berge J, Tamake HJ, Roos D, Schellekens PTA, Melief CJM, Zeijlemaker WP, Astaldi A (1982) Characterization of two subsets of human TG cells. J Immunol 128:1979–1985

    Google Scholar 

  7. Inoshita T, Whiteside TL, Rodnan GP, Taylor FH (1981) Abnormalities of T lymphocyte subsets in patients with progressive systemic sclerosis (PSS, scleroderma). J Lab Clin Med 97:264–277

    Google Scholar 

  8. Jablonska S (1975) Scleroderma and pseudoscleroderma. Warsaw, Polish Medical Publishers

    Google Scholar 

  9. Kahaleh MB, LeRoy EC (1983) Endothelial injury in scleroderma. J Lab Clin Med 101:553–560

    Google Scholar 

  10. Kamiński MJ, Majewski S, Jabŀońska S, Pawińska M (1984) Lowered angiogenic capability of peripheral blood lymphocytes in progressive systemic sclerosis (scleroderma). J Invest Dermatol 82:239–243

    Google Scholar 

  11. Kimber J (1985) Natural killer cells. Med Lab Sci 42:60–77

    Google Scholar 

  12. Majewski S, Skopińska-Różewska E, Jabŀońska S, Polakowski I, Pawińska M, Marczak M, Szmurŀo A (1985) Modulatory effect of sera from scleroderma patients on lymphocyte-induced angiogenesis. Arthritis Rheum 28:1133–1139

    Google Scholar 

  13. Moretta L, Webb S, Grossi C, Lydyard PM, Cooper MD (1977) Functional analysis of two T-cell subpopulations: help and suppression of B-cell response by T-cells bearing receptors for IgM or IgG. J Exp Med 146:184–200

    Google Scholar 

  14. Neville ME, Lischner WH (1982) Activation of Fc receptor-bearing lymphocytes by immune complexes. I. Stimulation of lymphokine production by nonadherent human peripheral blood lymphocytes. J Immunol 128:1063–1069

    Google Scholar 

  15. Penning CA, Cunningham J, French MAH, Harrison G, Rowell NR, Hughes P (1984) Antibody-dependent cellular cytotoxicity of human vascular endothelium in systemic sclerosis. Clin Exp Immunol 58:548–556

    Google Scholar 

  16. Reinherz EL, Penta AC, Hussey RE, Schlossman S (1981) A rapid method for separating functionally intact human T lymphocytes with monoclonal antibodies. Clin Immunol Immunopathol 21:257–262

    Google Scholar 

  17. Shen L, Lydyard PM, Penfold P, Roitt M (1979) Evidence for ADCC by T cells bearing receptors for IgG. Clin Exp Immunol 35:276–285

    Google Scholar 

  18. Sidky YA, Auerbach R (1975) Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs-host reaction. J Exp Med 141:1084–1100

    Google Scholar 

  19. Skopińska-Różewska E, Kamiński MJ, Nowaczyk M, Mościcka-Wesoŀowska M, Majewski S, Pazdur J, Malejczyk M (1985) Immunoregulatory action of ampicillin. Folia Biol (Prague) 31:200–212

    Google Scholar 

  20. Warrington RJ, Olivier S, Sander PJ, Rutheford WJ (1981) Production of MIF by purified human T cell subpopulation. Clin Exp Immunol 44:324–331

    Google Scholar 

  21. West WH, Cannon GB, Kay HD (1977) Natural cytotoxic reactivity of human lymphocytes against a myeloid cell line: characterization of effector cells. J Immunol 118:355–361

    Google Scholar 

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Authors and Affiliations

  1. Department of Gerontology, Medical Center of Postgraduate Education, Warsaw

    I. J. Polakowski & E. Skopińska-Różewska

  2. Department of Dermatology, Warsaw School of Medicine, Koszykowa 82A, PL-02-008, Warsaw

    S. Majewski & S. Jabŀońska

  3. Department of Laboratory Diagnostics and Clinical Immunology, Institute of Pediatrics, Warsaw

    E. Skopińska-Różewska & B. Wŀodarska

  4. Department of Immunology, Institute of Tuberculosis and Lung Diseases, Warsaw, Poland

    M. Żukowska

Authors
  1. I. J. Polakowski
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  2. S. Majewski
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  3. E. Skopińska-Różewska
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  4. M. Żukowska
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  5. B. Wŀodarska
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  6. S. Jabŀońska
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Additional information

Supported by a grant from the United Scleroderma Foundation, USA and by grant CPBP 06.01 from the Polish Academy of Sciences. Presented in part at the 5th ESDR/SID Joint Meeting, Geneva 1986

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Polakowski, I.J., Majewski, S., Skopińska-Różewska, E. et al. Modulatory effect of sera from scleroderma patients on lymphocyte-induced angiogenesis. II. Effector cells for the enhancing effect of acroscleroderma patients' sera. Arch Dermatol Res 280, 395–398 (1988). https://doi.org/10.1007/BF00429976

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  • DOI: https://doi.org/10.1007/BF00429976

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