Abstract
The effects of single and long-term haloperidol administration on rat open field behavior was studied. Withdrawal from long-term haloperidol treatment induced a significant increase in all parameters of activity recorded, expcept rearing. There was a direct relationship between the impairment of motor function induced by the single haloperidol administration and the increment of general activity observed after withdrawal from repeated drug administration. The results were considered to be a consequence of the supersensitivity of central dopaminergic receptors probably, of the mesostriatal pathway, that occurred in order to maintain the animal's homeostasis.
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References
Andén NE, Stock G (1973) Effect of clozapine on the turnover of dopamine in the corpus striatum and in the limbic system. J Pharm Pharmacol 25:346–348
Archer J (1973) Tests for emotionality in rats and mice: A review. Anim Behav 21:205–235
Asper H, Baggiolini M, Burki HR, Lauener H, Ruch W, Sille G (1973) Tolerance phenomena with neuroleptics. Catalepsy, apomorphine stereotypies on striatal dopamine metabolism in the rats after single and repeated administration of loxapine and haloperidol Eur J Pharmacol 22:287–294
Bernardi MM, Palermo Neto J (1979) Effects of abrupt and gradual withdrawal from long-term haloperidol treatment on open-field behavior of rats. Psychopharmacology 65:247–250
Broadhurst PL (1960) Experiments in psychogenetics. In: HJ Eysenck (ed) Experiments in personality, Vol 1. Routledge and Kegan Paul, London
Buus Lassen J (1976) Inhibition and potentiation of apomorphineinduced hypermotility in rats by neuroleptics. J Pharmacol 36:385–393
Collier HOJ (1968) Supersensitivity and dependence. Nature (Lond) 220:228–231
Cunha JM, Masur J (1978) Evaluation of psychotropic drugs with a modified open field test. Pharmacology 16:259–267
Fandrich E, Hadass H (1969) Relationship between the perazine concentration in the liver, brain and blood and the pharmacologic effects under chronic perazine medication in rats of different age. Pharmacopsychiat. Neuropsychopharm 2:109–111
Gessa GL, Tagliamonte A (1975) Effect of methadone and destromoramide on dopamine metabolism: Comparison with haloperidol and amphetamine. Neuropharmacology 14:913–920
Gianutsos G, Drawbaugh RB, Hynes MD, Lal H (1974) Behavioral evidence for dopaminergic supersensitivity after chronic haloperidol. Life Sci 14:887–898
Hornykiewicz O (1975) Parkinsonism induced by dopaminergic antagonists. In: Calne DB, Chase TN, Barbeau A (eds) Adv. neurol. dopaminergic mechanisms, Vol 9. Raven PRess, New York, pp 159–164
Janssen PAJ (1976) The pharmacology of haloperidol. Int J Neuropsychiat 3 (Suppl) 1:10–18
Johnson N, Leone F (1974) Statistics and experimental design. In: Engeneering and physical sciences. John Wiley, New York
MacLean PD, Delgado JMR (1976) Electrical and limbic system in the waking animal. Eletroenceph Clin Neurophysiol 5:91–100
Mahjn MA, Maickel RP (1969) Accumulation of phenothiazine tranquilizers in rat brain and plasma after repeated dosage. Biochem Pharmacol 18:270–271
Morrison DF (1976) Multivariate statistical methods. 2. ed. McGraw Hill, New York
Randrup A, Munkvad I (1974) Pharmacology and physiology of stereotyped behavior. J Psychiat Res 11:1–10
Setler P, Sarau H, McKenzie G (1976) Differential attenuation of some effects of haloperidol in rats given scopolamine. Eur J Pharmacol 39:117–126
Stawarz RJ, Hill H, Robinson SF, Setler P, Dingell JV, Sulser F (1975) On the significance of the increase in homovanilic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain. Psychopharmacologia 43:125–130
Tarsy D, Baldessarini RJ (1974) Behavioral supersensitivity to apomorphine following chronic treatment with drugs which interfere the synaptic function of catecholamines. Neuropharmacology 13:927–940
Thornburg JE, Moore KE (1974) Supersensitivity to dopaminergic agonists following withdrawal of a chronic diet containing haloperidol or pimozide. Pharmacologist 16:307–312
Ungerstedt U (1971) Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand (Suppl) 367:1–48
Walsh RN, Cummins RA (1976) The open field test; A critical review. Psychol Bull 86:482–504
Westerink BHC, Korf J (1976) Regional rat brain levels of 3,4-dihydroxyphenilacetic acid and homovanilic acid: Concurrent fluorimetric measurement and influence of drugs. Eur J Pharmacol 38:281–291
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Bernardi, M.M., De Souza, H. & Neto, J.P. Effects of single and long-term haloperidol administration on open field behavior of rats. Psychopharmacology 73, 171–175 (1981). https://doi.org/10.1007/BF00429212
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DOI: https://doi.org/10.1007/BF00429212