Abstract
Tiapride, a selective D2 dopaminergic receptor blocking agent from the substituted benzamide class, was evaluated in a blind video-controlled trial in 10 psychiatric patients with tardive dyskinesia. There was a significant decrease in dyskinesia with a parallel increase in parkinsonism. This relationship between two opposite effects on movement suggests a common pathophysiological basis lying on a reciprocal hyper- and hypoactivity of the dopaminergic striatal system. Nevertheless, other mechanisms may be involved, for the evolution of individual parkinsonian and dyskinesia scores is not necessarily opposite: the tiapride-induced parkinsonism was generally acceptable and in two cases, the dyskinesia scores were reduced without an increase in parkinsonism. Therefore, more dyskinetic patients have to be evaluated in long-term studies with tiapride, before this drug could be recommended in tardive dyskinesia, when dyskinetic movements become intolerable.
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References
Barnes TRE, Kidger T, Gore SM (1983) Tardive dyskinesia: a 3 year follow up study. Psychol Med 13:71–81
Bartholini G (1976) Differential effect of neuroleptic drugs on dopamine turn-over in the extrapyramidal disorders. J Pharm Pharmacol 28:429–433
Borenstein P, Champion C, Cujo P, Gekiere F, Olivenstein C, Kramarz P (1969) Un psychotrope original: le Sulpiride. Sem Hôp Paris, 45:1301–1314
Casey DE, Gerlach J (1980) Oxiperomide in tardive dyskinesia. J Neurol Neurosurg Psychiatry 43:264–267
Casey DE, Gerlach J, Simmelsgaard H (1979) Sulpiride in tardive dyskinesia. Psychopharmacology 66:73–77
Claveria LE, Teychenne PF, Calne DB, Haskayne L, Petrie A, Pallis CA, Lodge-Patch IC (1975) Tardive dyskinesia treated with pimozide. J Neurol Sci 24:393–401
Corsini GU, Del Zompo M, Cianchetti C, Mangoni A (1976) Therapeutical efficacy of a combination of apomorphine with sulpiride or metoclopramide in parkinsonism. Psychopharmacology 47:169–173
Costall B, Naylor RJ (1977) Démonstration neuropharmacologique de l'effect antidyskinétique du Tiapride. Sem Hôp Paris 53:73–76
Gerlach J, Simmelsgaard H (1978) Tardive dyskinesia during and following treatment with haloperidol, haloperidol+biperiden, thioridazine and clozapine. Psychopharmacology 59:105–112
Jenner P, Marsden CD (1981) Substituted benzamide drugs as selective neuroleptic agents. Neuropharmacology 20:1285–1293
Kazamatsuri H, Chien CP, Cole JO (1972) Treatment of tardive dyskinesia. II. Short-term efficacy of dopamine-blocking agents. Arch Gen Psychiatry 27:100–103
Kebabian JW, Calne DB (1979) Multiple receptors for dopamine. Nature 277:93–96
Klawans HL (1973) The pharmacology of tardive dyskinesias. Am J Psychiatry 130:82–86
Lavy S, Melamed E, Penchas S (1978) Tardive dyskinesias associated with metoclopramide. Br Med J 1:77–78
Lees AJ, Lander CM, Stern GM (1979) Tiapride in levodopa-induced involuntary movements. J Neurol neurosurg Psychiatry 42:380–383
Lhermitte F, Agid Y, Feuerstein C, Serre F, Signoret JL, Studler JM, Bonnet AM (1977a) Mouvements anormaux provoqués par la L-dopa dans la maladie de Parkinson. Corrélations avec les concentrations plasmatiques de dopa et de O-méthoxy-dopa. Rev Neurol 133:445–454
Lhermitte F, Signoret JL, Agid Y (1977b) Etude des effects d'une molécule originale, le Tiapride, dans le traitement des mouvements anormaux d'origine extra-pyramidale. Sem Hôp Paris 53:9–15
Niemegeers CJE, Janssen PAJ (1979) A systematic study of the pharmacological activities of dopamine antagonists. Life Sci 24:2201–2216
Pollak P, Gaio JM, Hommel M, Pellat J, Perret J, Chateau R (1982) Modifications de symptômes extra-pyramidaux par l'apomorphine associée à différents antagonistes dopaminergiques. Rev Neurol 138:409–413
Schachter M, Bedard P, Debono AG, Jenner P, Marsden CD, Price P, Parkes JD, Keeman J, Smith B, Rosenthaler J, Horowqki R, Dorow R (1980) The role of D1 and D2 receptors. Nature 286:157–159
Simpson GM, Lee JH, Shrivastava RK (1979) Clozapine in tardive dyskinesia. Psychopharmacology 64:171–179
Sokoloff P, Martres MP, Schwartz JC (1980) Three classes of dopamine-receptors (D-2, D-3, D-4) identified by binding studies with 3H-apomorphine and 3H-domperidone. Naunyn-Schmiedeberg's Arch Pharmacol 315:89–102
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Pollak, P., Gaio, JM., Hommel, M. et al. Effects of tiapride in tardive dyskinesia. Psychopharmacology 85, 236–239 (1985). https://doi.org/10.1007/BF00428422
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DOI: https://doi.org/10.1007/BF00428422