Summary
After animal experiments suggested there was an interaction between growth hormone and bone healing, our aim in this paper was to ascertain whether there were any changes or possible interaction between the serum level of growth hormone, somatomedin C and alkaline phosphatase while a fractured bone was healing. To this end, the serum concentrations of growth hormone, somatomedin C, alkaline phosphatase and calcium were ascertained both pre- and post-operatively in two groups of patients — one with bone operations, the other with soft-tissue operations — and the results were compared. Comparing the groups, we found that after bone operations there was no increase in the serum level of growth hormone, nor of somatomedin C. An increase would have implied that these two hormones are directly involved in bone regeneration. There was no change in the serum level of alkaline phosphatase or calcium after either bone or soft-tissue operations.
Zusammenfassung
Nach tierexperimentellen Studien, die auf eine Wechselwirkung von Wachstumshormon und Knochenbruchheilung schließen ließen, war es Ziel dieser Arbeit festzustellen, ob es im Verlauf einer Knochenbruchheilung zu signifikanten Änderungen oder möglichen Wechselwirkungen zwischen dem Serumspiegel von Wachstumshormon, Somatomedin C and alkalischer Phosphatase kommt. Zu diesem Zweck wurden die Ergebnisse der prä- und postoperativ ermittelten Serumkonzentrationen des Wachstumshormons, des Somatomedin C, der alkalischen Phosphatase und des Kalziums eines Patientenkollektivs mit Knocheneingriffen und einer Patientengruppe mit Weichteiloperationen miteinander verglichen. Während des Untersuchungszeitraums fanden wir im Vergleich der beiden Gruppen weder für das Wachstumshormon noch für das Somatomedin C einen Anstieg des Serumspiegels in der Gruppe der Knochenoperationen, der den Schluß zugelassen hätte, daß beide Hormone direkt an der knöchernen Konsolidierung beteiligt sind. Ebenso konnte keine Änderung des Serumspiegels von alkalischer Phosphatase und Kalzium nach Knochen- oder Weichteiloperationen festgestellt werden.
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Dedicated to Prof. Dr. med. J. Ohnsorge on his 53rd birthday
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Casser, H.R., Zilkens, K.W., Forst, R. et al. Influence of bone and soft-tissue operations on serum concentrations of growth hormone, somatomedin C and alkaline phosphatase. Arch Orthop Trauma Surg 109, 272–276 (1990). https://doi.org/10.1007/BF00419943
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DOI: https://doi.org/10.1007/BF00419943