Abstract
The binding between marcrophage-like cells J774G8 and Leishmania braziliensis (NR) promastigotes was studied ‘in vitro’ by a radioisotopic assay under various conditions in the absence of serum. Different sugars, N-acetyl-D-glucosamine, D-glucose, D-mannose, D-galactose, and chitin, diminished the binding of the parasite, whereas other sugars, D-arabinose, D-fucose and D-xylose, did not affect the binding. The presence of a lectin-like ligand specific for N-acetyl-D-glucosamine has been detected on the cell surface of the Leishmania braziliensis (NR) by fluorescence microscopy.
These data suggest that the binding of the parasite to the host's cell is a ligand-receptor interaction which involves the participation of a lectin-like component on the parasite cell surface.
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Hernández, A.G., Rodríguez, N., Stojanovic, D. et al. The localization of a lectin-like component on the Leishmania cell surface. Mol Biol Rep 11, 149–153 (1986). https://doi.org/10.1007/BF00419735
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DOI: https://doi.org/10.1007/BF00419735