Summary
Reserpine treatment in doses of 1.0 and 5.0 mg/kg body weight, given 6 h before antigen challenge significantly suppresses the contact sensitivity reaction to picryl chloride in sensitized mice. The suppression involves both the edema formation, measured as ear swelling, and the accumulation of inflammatory cells at the test site. This is probably mediated through inhibition of the release of vasoactive amines from local mast cells.
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References
Askenase PW, Bursztajn S, Gershon MD, Gershon RK (1980) T cell-dependent mast cell degranulation and release of serotonin in murine delayed-type hypersensitivity. J Exp Med 152:1358–1374
Bäck O, Larsen A (1982) Contact sensitivity in mice evaluated by means of ear swelling and a radiometric test. J Invest Dermatol 78:309–312
Bäck O, Groth O (1983) The cellular infiltrate of the contact sensitivity reaction to picryl chloride in the mouse. Acta Derm Venereol (Stockh) 63:304–307
Gershon RK, Askenase PW, Gershon MD (1975) Requirement for vasoactive amines for production of delayed-type hypersensitivity skin reactions. J Exp Med 142:732–747
Polák L, Turk JL (1969) The effect of antihypertensive agents on the peripheral manifestations of allergic and other inflammatory reactions in the skin. Int Arch Allergy Appl Immunol 36:442–449
Schnyder WW, Storck H (1956) Tierexperimentelle Untersuchungen über die Beeinflussung von ekzematösen Hautreaktionen durch Neuroplegica. Dermatologica 112:419–425
Thomas WR, Vardinon N, Watkins MD, Asherson GL (1980) Antigen-specific mast cell degranulation in contact sensitivity to picryl chloride. An early event. Immunology 39:331–336
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Bäck, O., Groth, O. Reserpine and the suppression of both edema formation and cellular infiltrate of the contact sensitivity reaction in the mouse. Arch Dermatol Res 275, 371–373 (1983). https://doi.org/10.1007/BF00417335
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DOI: https://doi.org/10.1007/BF00417335