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Pilin independent binding of Neisseria gonorrhoeae to immobilized glycolipids

  • Section 2: Neisseria Genetics
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Abstract

The adherence process in pathogenesis involves the attachment of bacteria to structures present on eukaryotic cell surfaces. To investigate components necessary for this interaction, we have characterized the binding of N. gonorrhoeae to eukaryotic glycolipids immobilized on thin layer chromatograms. The gonococci specifically bind to a subset of glycolipids consisting of lactosylceramide, gangliotriosylceramide, and gangliotetraosylceramide. This binding was identified in both piliated and nonpiliated cells, and is postulated to be mediated by a nonpilin lectin-like adhesin protein.

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Authors and Affiliations

  1. Dept. of Molecular Biology, Research Institute of Scripps Clinic, 92037, La Jolla, CA, USA

    C. D. Deal & M. So

  2. Dept. of Medical Biochemistry, University of Goteborg, Goteborg, Sweden

    N. Stromberg & K. -A. Karlsson

  3. Dept. of Microbiology, University of Umea, Umea, Sweden

    G. Nyberg & S. Normark

Authors
  1. C. D. Deal
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  2. N. Stromberg
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  3. G. Nyberg
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  4. S. Normark
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  5. K. -A. Karlsson
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  6. M. So
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Deal, C.D., Stromberg, N., Nyberg, G. et al. Pilin independent binding of Neisseria gonorrhoeae to immobilized glycolipids. Antonie van Leeuwenhoek 53, 425–430 (1987). https://doi.org/10.1007/BF00415497

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  • DOI: https://doi.org/10.1007/BF00415497

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