Summary
Renal allograft recipients were shown to have an increased incidence of warts and skin cancers. We examined 148 patients for evidence of wart virus infections and tested for papillomavirus types, which are known to be associated with human malignancies. Of the 148, 36 (24.3%) patients were afflicted with warts at the end of our study period, in contrast to 5 of 148 (3.3%) before transplantation. DNA from 16 different biopsies was extracted by phenol treatment for further virological studies. DNA of human papillomavirus (HPV) 2 was detected three times, DNA of HPV 4 and 10 twice, and DNA of HPV 3 and 16 once each by blot hybridization. One probe led to strong signals with HPV types previously found only in epidermodysplasia verruciformis patients. A correlation between histology and virus type exsisted in cases of HPV 2, 3, 4, and 10 infections.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Barnett N, Mak H, Winkelstein JA (1983) Extensive verrucosis in primary immuno-deficiency diseases. Arch Dermatol 119:5–7
Boshart M, Gissmann L, Ikenberg H, Kleinheinz A, Scheurlen W, zur Hausen H (1984) A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer. EMBO J 3:1151–1157
Dürst M, Gissmann L, Ikenberg H, zur Hausen H (1983) A new type of papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsies from different geographic regions. Proc Natl Acad Sci USA 80:3812–3815
Gassenmaier A, Lammel M, Pfister H (1984) Molecular cloning and characterization of the DNAs of human papillomaviruses 19, 20 and 25 from a patient with epidermodysplasia verruciformis. J Virol 52:1019–1023
Glinski W, Obalek S, Jablonska S, Orth G (1981) T cell defect in patients with epidermodysplasia verruciformis due to human papillomavirus type 3 and 5. Dermatologica 162:141–147
Gross G, Pfister H, Hagedorn W, Gissmann L (1982) Correlation between human papillomavirus (HPV) type and histology of warts. J Invest Dermatol 78:160–164
Hoover R, Fraumeni JF (1973) Risk of cancer in renaltransplant recipients. Lancet 2:55–57
Hoxtell EO, Mandel JS, Murray SS, Schuman LM, Goltz RW (1977) Incidence of skin carcinoma after renal transplantation. Arch Dermatol 113:436–438
Ingelfinger JR, Grupe WE, Topor M, Levey RH (1977) Warts in a pediatric renal transplant population. Dermatologica 155:7–12
Jablonska S, Orth G, Glinski G, Obalek S, Jarzabek-Chorzelska M, Croissant O, Favre M, Rzesa G (1980) Morphology and immunology of human warts and familial warts. In: Bachmann PA (ed) Leukaemias, lymphomas and papillomas: comparative aspects. Taylor and Francis, London, pp 107–131
Jablonska S (1984) Wart viruses: Human papillomaviruses. Semin Dermatol 3:120–129
Koranda FC, Dehmel EM, Kahn G, Penn I (1974) Cutaneous complications in immunosuppressed renal homograft recipients. J Am Med Assoc 229:419–424
Kremsdorf D, Favre M, Jablonska S, Obalek S, Rucda AL, Lutzner M, Blanchet-Bardon C, van Voorst Vader PC, Orth G (1984) Molecular cloning and characterization of the genomes of nine newly recognized human papillomavirus types associated with epidermodysplasia verruciformis. J Virol 52:1013–1018
Lutzner M, Croissant O, Ducasse MF, Kreis H, Crosnier J, Orth G (1980) A potentially oncogenic human papillomavirus (HPV 5) found in two renal allograft recipients. J Invest Dermatol 75:353–356
Merion RM, White DJG, Thiru S, Evans DB, Calne RY (1984) Cyclosporine: Five years experience in cadaveric renal transplantation. N Engl J Med 310:148–158
Morison WL (1975) Viral warts, herpes simplex and herpes zoster in patients with secondary immune deficiencies and neoplasms. Br J Dermatol 92:625–630
Mullen DL, Silverberg SG, Penn I, Hammond WS (1976) Squamous cell carcinoma of the skin and lip in renal homograft recipients. Cancer 37:729–734
Obalek S, Glinski W, Haftek M, Orth G, Jablonska S (1980) Comparative studies on cell-mediated immunity in patients with different warts. Dermatologica 161:73–83
Orth G, Jablonska S, Jarzabek-Chorzelska M, Obalek S, Rzesa G, Favre M, Croissant O (1979) Characteristics of the lesions and risk of malignant conversion associated with the type of human papillomavirus involved in epidermodysplasia verruciformis. Cancer Res 39:1074–1082
Ostrow RS, Zachow K, Thompson O, van der Leest R, Bender M, Faras A (1983) Physical characterization of unique HPV DNAs. EMBO Workshop on Papilloma Viruses, Örenas, Sweden, July, p 57
Ostrow RS, Zachow HR, Thompson O, Faras A (1984) Molecular cloning and characterization of a unique type of human papillomavirus from an immune deficient patient. J Invest Dermatol 82:362–366
Pfister H, Gross G, Hagedorn M (1979) Characterization of human papillomavirus 3 in warts of a renal allograft patient. J Invest Dermatol 73:349–353
Pfister H (1984) Biology and Biochemistry of papillomaviruses. Rev Physiol Biochem Pharmacol 99:112–181
Pfister H, Haneke E (1984) Demonstration of human papilloma virus type 2 DNA in Bowen's disease. Arch Dermatol Res 276:123–125
Prawer SE, Pass F, Vance JC, Greenberg LJ, Yunis EJ, Zelickson AS (1977) Depressed immune functions in epidermodysplasia verruciformis. Arch Dermatol 113: 495–499
Reid TMS, Fraser NG, Kernohan IR (1976) Generalized warts and immune deficiency. Br J Dermatol 95:559–564
Southern EM (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98:503–517
Spencer E, Andersen HK (1970) Clinically evident, nonterminal infections with herpes viruses and the wart virus in immunosuppressed renal allograft recipients. Br Med J 3:251–254
Spencer ES, Andersen HK (1969) Viral infections in renal allograft recipients treated with long-term immunosuppression. Br Med J 2:829–830
Zur Hausen H, Schulte-Holthausen H, Klein G, Henle W, Henle G, Clifford P, Santesson L (1970) EBV-DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the nasopharynx. Nature (Lond) 228:1056–1058
Author information
Authors and Affiliations
Additional information
This work is dedicated to Professor Otto Paul Hornstein on his 60th birthday
Rights and permissions
About this article
Cite this article
Gassenmaier, A., Fuchs, P., Schell, H. et al. Papillomavirus DNA in warts of immunosuppressed renal allograft recipients. Arch Dermatol Res 278, 219–223 (1986). https://doi.org/10.1007/BF00412927
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00412927