Skip to main content
SpringerLink
Log in

Polymorphonuclear granulocyte chemotaxis and chemotactic factor generation by concanavalin A-stimulated peripheral blood mononuclear cells in patients with psoriasis

  • Original Contributions
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Summary

Polymorphonuclear leukocytes from patients with psoriasis demonstrated a significantly enhanced chemotactic responsiveness to zymosanactivated human serum as compared to granulocytes from healthy volunteers. Furthermore, psoriatic peripheral blood mononuclear cells stimulated with concanavalin A produced an increased amount of lymphocyte derived chemotactic factor (LDCF) as compared to that in the case of healthy persons. The LDCF proved to be chemokinetic for the psoriatic granulocyte.

It is postulated that these two phenomena may play a role in the pathogenesis of psoriasis.

Zusammenfassung

Die polymorphkernigen Leukocyten von Patienten mit Psoriasis zeigten eine signifikant gesteigerte chemotaktische Reaktionsfähigkeit gegen Zymosan-aktiviertes menschliches Serum im Vergleich zu Granulocyten von gesunden Personen. Weiterhin produzierten mit Concanavalin A stimulierte psoriatische mononucleare Zellen verglichen mit denen gesunder Personen mehr lymphocytenstämmigen chemotaktischen Faktor (lymphocyte-derived chemotactic factor-LDCF). LDCF erwies sich als chemokinetisch für die psoriatischen Granulocyten. Es wird vermutet, daß diese Phänomena in der Pathogenese der Psoriasis eine Rolle spielen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Boyden S (1962) The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leukocytes. J Exp Med 115:453–466

    Article  PubMed  Google Scholar 

  2. Bresnihan B, Jasin HE (1977) Suppressor function of peripheral blood mononuclear cells in normal individuals and in patients with systemic lupus erythematosus. J Clin Invest 59:106–116

    PubMed  Google Scholar 

  3. Cormane RH, Hunyadi J, Hamerlinck F (1976) The role of lymphoid cells and polymorphonuclear leukocytes in the pathogenesis of psoriasis. Psoriasis. In: Farber EM, Cox AJ (eds) Proceedings of the second international symposium. Yorke Medical Books, New York, pp 47–54

    Google Scholar 

  4. Csató M, Dobozy A, Simon N (1980) Study of phagocytic function with a quantitative nitrobluetetrazolium reduction test in diabetes mellitus. Arch Dermatol Res 268:283–288

    PubMed  Google Scholar 

  5. Densen P, Mandell GL (1978) Gonococcal interactions with polymorphonuclear neutrophils. Importance of the phagosome for bactericidal activity. J Clin Invest 62:1161–1171

    PubMed  Google Scholar 

  6. Djawari D, Bischoff T, Hornstein OP (1978) Impairment of chemotactic activity of microphages in chronic mucocutaneous candidosis. Arch Dermatol Res 262:247–253

    PubMed  Google Scholar 

  7. Fernandez LA, Macsween JM (1980) Generation of suppressor cells by concanavalin A. A new perspective. J Immunol 125:267–270

    PubMed  Google Scholar 

  8. Hunyadi J, Dobozy A, Kenderessy SzA, Simon N (1980) Suppressor function of peripheral blood mononuclear cells in patients with psoriasis vulgaris. J Invest Dermatol 75:217–218

    Article  PubMed  Google Scholar 

  9. Jablonska S, Beutner E, Binder WL, Chorzelska M, Rzesa G, Chovianec O (1979) Immunopathology of psoriasis. Arch Dermatol Res 264:65–71

    PubMed  Google Scholar 

  10. Kawohl G, Szperalski B, Schröder JM, Christophers E (1980) Polymorphonuclear leukocyte chemotaxis in psoriasis: enhancement by self-activated serum. Br J Derm 103:527–533

    PubMed  Google Scholar 

  11. Langhof H, Müller H (1966) Leukotaktische Eigenschaften von Psoriasisschuppen Hautarzt 17:101–105

    PubMed  Google Scholar 

  12. Lazarus GS, Yost FJ, Thomas CA (1977) Polymorphonuclear leukocytes: Possible mechanism of accumulation in psoriasis. Science 198:1162–1163

    PubMed  Google Scholar 

  13. Lukács K, Kávai M, Sonkoly I, Sipka S, Dezsö B, Szegedi Gy (1980) Monocita kemotaxis és limfokin aktivitás systemás lupus erythematosusban. Magyar Reumatol 21:22–26

    Google Scholar 

  14. Michaelsson G (1980) Increased chemotactic activity of neutrophil leukocytes in psoriasis. Br J Derm 103:351–356

    PubMed  Google Scholar 

  15. Sauder DN, Bailin PL, Sundeen J, Krahauer RS (1980) Suppressor cell function in psoriasis. Arch Dermatol 1:51–56

    Article  Google Scholar 

  16. Tagami H, Ofuji S (1976) Leukotactive properties of soluble substances in psoriasis scale. Br J Dermatol 95:1–8

    PubMed  Google Scholar 

  17. Wahba A, Cohen HA, Bar-Eli M, Gallily R (1978) Enhanced chemotactic and phagocytic activities of leukocytes in psoriasis. J Invest Dermatol 71:186–188

    Article  PubMed  Google Scholar 

  18. Wahba A, Cohen H, Bar-Eli M, Gallily R (1979) Neutrophil chemotaxis in psoriasis. Acta Derm Venereol (Stockh) 59:441–445

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Dept. of Dermatology, University Medical School, POB 480, H-6701, Szeged, Hungary

    M. Csató, A. Dobozy, J. Hunyadi, Sz. A. Kenderessy & N. Simon

Authors
  1. M. Csató
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Dobozy
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. Hunyadi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sz. A. Kenderessy
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. N. Simon
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Csató, M., Dobozy, A., Hunyadi, J. et al. Polymorphonuclear granulocyte chemotaxis and chemotactic factor generation by concanavalin A-stimulated peripheral blood mononuclear cells in patients with psoriasis. Arch Dermatol Res 271, 259–264 (1981). https://doi.org/10.1007/BF00409454

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00409454

Key words

Schlüsselwörter

Search

Navigation