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A comparison of the antihypertensive action of propranolol and the optical isomers of N-isopropyl-p-nitrophenylethanolamine (INPEA)

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Summary

In hypertensive patients, the effect of propranolol and of the optical isomers of N-isopropyl-p-nitrophenylethanolamine (INPEA) on blood pressure was studied. Single oral doses of 40 mg propranolol, 700 mg (−)-INPEA and 700 mg (+)-INPEA decreased supine systolic as well as standing systolic and diastolic blood pressure. Single intravenous doses of 75 mg (−)-INPEA and 75 mg (+)-INPEA lowered supine systolic and diastolic blood pressure. The antihypertensive action of the beta adrenergic blocking levorotatory isomer of INPEA and of the dextrorotatory isomer, which is devoid of beta adrenergic blocking activity, did not differ. It is concluded from these results that the antihypertensive action of beta adrenergic blocking agents is not related to their beta receptor blocking effect.

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Authors and Affiliations

  1. II. Med. Klinik und Poliklinik der Universität, Langenbeckstr. 1, 65, Mainz

    H. J Gilfrich &  K. H. Rahn

  2. Med. Kliniken und Polikliniken der Universität, Klinikstr. 32, 63, Gießen

    F. W. Schmahl

Authors
  1. H. J Gilfrich
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  2. K. H. Rahn
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  3. F. W. Schmahl
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Additional information

A preliminary report has been presented. H. J. Gilfrich, K. H. Rahn und F. W. Schmahl, Verhandlungen der Deutschen Gesellschaft für Innere Medizin 74, 562 (1968).

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Gilfrich, H.J., Rahn, K.H. & Schmahl, F.W. A comparison of the antihypertensive action of propranolol and the optical isomers of N-isopropyl-p-nitrophenylethanolamine (INPEA). Pharmacol. Clin. 2, 30–33 (1969). https://doi.org/10.1007/BF00404183

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  • DOI: https://doi.org/10.1007/BF00404183

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