Abstract
Desipramine in intravenous doses of 0.3 to 3 mg/kg in the cat enhances preganglionic cervical sympathetic nerve activity evoked by hypothalamic stimulation. This effect is dependent on the pulse frequency of stimulation. Spontaneous potentials are in general slightly diminished. Reflex excitation of preganglionic sympathetic outflow induced by sciatic nerve stimulation is not altered by desipramine. The described effects are interpreted as the result of a modulating influence of desipramine on central structures controlling sympathetic outflow.
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Augulis, V., Sepinwall, J.: Brazilin-Toluidine blue O and Hematoxylin-Darrow red methods for brain and spinal cord. Stain Technol. 44, 131–137 (1969).
Bronk, D. W., Pitts, R. F., Larrabee, M. G.: Role of hypothalamus in cardiovascular regulation. Res. Publ. Ass. nerv. ment. Dis. 20, 231–341 (1939).
Dobkin, A. B.: Potentiation of thiopental anesthesia by derivatives and analogues of phenothiazine. Anesthesiology 21, 292–296 (1960).
Domenjoz, R., Theobald, W.: Zur Pharmakologie des Tofranil [N-(3-dimethylaminopropyl)-iminodibenzyl-hydrochlorid]. Arch. int. Pharmacodyn. 120, 450–489 (1959).
Green, J. H.: Physiology of baroreceptor function: Mechanism of receptor stimulation. Baroreceptors and Hypertension, pp. 3–14. P. Kezdi, Ed. London: Pergamon Press 1967.
Horovitz, Z. P., Chow, M., Carlton, P. L.: Self-stimulation of the brain by cats: Effect of imipramine, amphetamine and chlorpromazine. Psychopharmacologia (Berl.) 3, 455–462 (1962).
Kato, R., Chiesara, E., Vassanelli, P.: Mechanism of potentiation of barbiturates and meprobamate actions by imipramine. Biochem. Pharmacol. 12, 357–364 (1963).
Kreppel, E.: Zur Beeinflussung vegetativer Efferenzen durch Phenothiazine und ähnliche Stoffe. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 253, 58–61 (1966).
Penaloza-Rojas, J. H., Bach-Y-Rita, G., Rubio-Chevannier, H. F., Hernandez-Peon, R.: Effects of imipramine upon hypothalamic and amygdaloid excitability. Exp. Neurol. 4, 205–214 (1961).
Rubio-Chevannier, H., Bach-Y-Rita, G., Penaloza-Rojas, J., Hernandez-Peon, R.: Potentiating action of imipramine upon reticular arousal. Exp. Neurol. 4, 214–220 (1961).
Schmitt, H., Schmitt, H.: Actions modératrices des antidepresseur groupe de l'imipramine sur les centres cardiovasculaires. Arch. int. Pharmacodyn. 165, 276–290 (1967).
Sigg, E. B.: Pharmacological studies with tofranil. Canad. Psychiat. Ass. J. 4 (Suppl.), 75–85 (1959).
- Tricyclic thymoleptic agents and some newer antidepressants. Psychopharmacology-Ten Years of Progress, U.S. Public Health Public. 1836, 655–669 (1968).
Sigg, E. B., Sigg, T. D.: Hypothalamic stimulation of preganglionic autonomic activity and its modification by chlorpromazine, diazepam, and pentobarbital. Int. J. Neuropharmacol. 8, 567–572 (1969).
Snider, R. S., Niemer, W. T.: A Stereotaxic Atlas of the Cat Brain. Chicago: University of Chicago Press 1961.
Stein, L., Wise, C. D.: Release of norepinephrine from hypothalamus and amygdala by rewarding medial forebrain bundle stimulation and amphetamine. J. comp. physiol. Psychol. 67, 189–198 (1969).
Sulser, F., Owens, M. L., Strada, S. J., Dingell, J. V.: Modification by desipramine (DMI) of the availability of norepinephrine released by reserpine in the hypothalamus of the rat in vivo. J. Pharmacol. exp. Ther. 168, 272–282 (1969).
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Sigg, E.B., Keim, K.L. Enhancement by desipramine of hypothalamically evoked discharges in preganglionic sympathetic nerves. Psychopharmacologia 18, 378–386 (1970). https://doi.org/10.1007/BF00402764
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DOI: https://doi.org/10.1007/BF00402764