Summary
Telomeric fusion, a rare phenomenon, was observed in malignant cells from the peripheral blood of an 18-year-old male with rapidly progressive pre-T-cell acute lymphoblastic leukemia (ALL). Only two comparable cases, both with B-cell ALL, have been reported with telomeric fusion in neoplasia. All of the leukemic cells examined from our patient had two chromosome abnormalities consisting of partial triplication (trp) of chromosome 2 and a derivative chromosome 3. Approximately a third of the leukemic cells showed in addition telomere-telomere fusions. These involved the telomeric regions of 1p, 2p, 4q, 5q, 7q, 10q, 11q, 12p, 15p, 21p, and Xq and 3p of the derivative (3). The findings in this case suggest that telomeric fusion may function as a mechanism for the development of chromosome rearrangements that may play a role, albeit rarely, in human neoplasia.
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References
Benn PA (1976) Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos. Am J Hum Genet 28:465–473
Bernard A, Boumsell L, Reinherz EL, Nadler LM, Ritz J, Coppin H, Richard Y, Valensi F, Dausset J, Flandrin G, Lemerle J, Schlossman SF (1981) Cell surface characterization of malignant T cells from lymphoblastic lymphoma using monoclonal antibodies: evidence for phenotypic differences between malignant T cells from patients with acute lymphoblastic leukemia and lymphoblastic lymphoma. Blood 57:1105–1110
Cavalier-Smith T (1983) Cloning chromosome ends. Nature 301:112–113
Chen TR (1974) A simple method to sequentially reveal Q- and C-bands on the same metaphase chromosomes. Chromosoma 47:147–156
Dancis BM, Holmquist GP (1977) Fusion model of telomere replication and its implications for chromosomal rearrangements. Chromosomes Today 6:95–104
Dutrillaux B, Aurias A, Couturier J, Croquette MF, Viegas-Pequignot E (1977) Multiple telomeric fusions and chain configurations in human somatic chromosomes. Chromosomes Today 6:37–44
Dutrillaux B, Croquette MF, Viegas-Pequignot E, Aurias A, Coget J, Couturier J, Lejeune J (1978) Human somatic chromosome chains and rings. A preliminary note on end-to-end fusions. Cytogenet Cell Genet 20:70–77
Fitzgerald PH, Morris CM (1984) Telomeric association of chromosomes in B-cell lymphoid leukemia. Hum Genet 67:385–390
Hayashi K, Schmid W (1975) Tandem duplication q14 and dicentric formation by end-to-end chromosome fusions in ataxia telangiectasia (AT). Humangenetik 30:135–141
Hsu TC, Pathak S, Chen TR (1975) The possibility of latent centromeres and a proposed nomenclature system for total chromosome and whole arm translocations. Cytogenet Cell Genet 15:41–49
ISCN (1985) Harnden DG, Klinger MP (eds) An international system for human cytogenetic nomenclature. Karger, Basel
King BO, Yao M-C (1982) Tandemly repeated hexanucleotide at tetrahymena rDNA free end is generated from a single copy during development. Cell 31:177–182
Moorhead PS, Saksela E (1963) Non-random chromosomal aberrations in SV40-transformed human cells. J Cell Comp Physiol 62:57–83
Morris CM, Fitzgerald PH, Neville MA, Wyld PJ, Beard MEJ (1984) Does multisomy of chromosome 1q confer a proliferative advantage in B-cell acute lymphoblastic leukemia? Cancer 54:48–53
Nadler LM, Slashenko P, Hardy R, Pesando JM, Yunis EJ, Schlossman SF (1981) Monoclonal antibodies defining seralogically distinct HLA-D/DR related Ia-like antigens in man. Hum Immunol 1:77
Novitski E, Grace D, Strommen C, Puro J (1981) Terminal chromosome attachments. Am J Hum Genet 33:55–60
Oxford JM, Harnden DG, Parrington JM, Delhanty JDA (1975) Specific chromosome aberrations in ataxia telangiectasia. J Med Genet 12:251–262
Ritz J, Pesando JM, Notis-McConarty J, Lazarus H, Schlossman SF (1980) A monoclonal antibody to human acute lymphoblastic leukemia antigen. Nature 283:583
Ritz J, Nadler LM, Bhan AJ, Notis-McConarty J, Pesando JM, Schlossman SF (1981) Expression of common acute lymphoblastic leukemia antigen (CALLA) by lymphomas of B cell and T cell lineage. Blood 58:648
Sandberg AA (1980) The chromosomes in human cancer and leukemia. Elsevier/North-Holland, New York
Szostak JW, Blackburn EH (1982) Cloning yeast telomeres on linear plasmid vectors. Cell 29:245–255
Taylor AMR, Oxford JM, Metcalfe JA (1981) Spontaneous cytogenetic abnormalities in lymphocytes from thirteen patients with ataxia telangiectasia. Int J Cancer 27:311–319
White MJD (1973) Animal cytology and evolution, 3rd edn. University Press, Cambridge
Wolman SR, Hirschhorn K, Todaro GJ (1964) Early chromosomal changes in SV40-infected human fibroblast cultures. Cytogenetics 3:45–61
Wolman SR, Steinberg ML, Defendi V (1980) Simian virus 40-induced chromosome changes in human epidermal cultures. Cancer Genet Cytogenet 2:39–46
Yerganian G, Shein HM, Enders JF (1962) Chromosomal disturbances observed in human fetal renal cells transformed in vitro by Simian virus 40 and carried in culture. Cytogenetics 1:314–324
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Morgan, R., Jarzabek, V., Jaffe, J.P. et al. Telomeric fusion in pre-T-cell acute lymphoblastic leukemia. Hum Genet 73, 260–263 (1986). https://doi.org/10.1007/BF00401240
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DOI: https://doi.org/10.1007/BF00401240