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Enhanced activity of anticancer drugs in murine tumours by co-administration with 3-aminopyrrolidine-2,5-dione-N-mustard derivative

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  • Experimental Oncology
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Summary

(R,S)3-{N,N-[bis-(2-chloroethyl)]-amino}-1-(2′-methoxyphenyl)-pyrrolidine-2,5-dione hydrochloride (I) has shown antitumor activity against P388 and L1210 leukaemias and Sarcoma 180 (ascites). The effect of (I), when co-administered with anticancer drugs, was studied in these murine tumours. Although co-administration of (I) with methotrexate showed a significant increase of the activity against P388 and L1210 leukaemias and Sarcoma 180 (ascites), co-administration of (I) with 5-fluorouracil, mitomycin C, adriamycin or vincristine did not exhibit any enhancing, synergistic or additive effect in the activity of these drugs.

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Authors and Affiliations

  1. Bio-Organic Unit, Cancer Research Institute, Tata Memorial Centre, Parel, 400012, Bombay, India

    Ramkrishna Y. Ambaye, Manohar A. Indap & Satish D. Naik

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  1. Ramkrishna Y. Ambaye
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  2. Manohar A. Indap
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  3. Satish D. Naik
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Ambaye, R.Y., Indap, M.A. & Naik, S.D. Enhanced activity of anticancer drugs in murine tumours by co-administration with 3-aminopyrrolidine-2,5-dione-N-mustard derivative. J Cancer Res Clin Oncol 115, 379–382 (1989). https://doi.org/10.1007/BF00400966

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  • DOI: https://doi.org/10.1007/BF00400966

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