Summary
A total of 44 extrahepatic bile duct carcinomas comprising 13 well-differentiated adenocarcinomas, 25 moderately differentiated adenocarcinomas, and 6 poorly differentiated adenocarcinomas were examined histologically and immunohistochemically for somatostatin, gastrin, and glicentin. Argyrophil cells, argentaffin cells, and somatostatin- and gastrin-immunoreactive cells within the tumor were detected in 46.2%, 15.4%, 23.1%, and 15.4% of well-differentiated adenocarcinomas, and in 16.0%, 8.0%, 12.0%, and 4.0% of moderately differentiated adenocarcinomas, respectively. No tumor tissues of poorly differentiated adenocarcinomas contained endocrine cells. A statistically significant difference in the frequency of argyrophil cells was observed between well and poorly differentiated adenocarcinoma. The incidence of argyrophil cells and somatostatin-immunoreactive cells in nonneoplastic mucosa adjacent to well-differentiated adenocarcinoma was higher than in that adjacent to poorly differentiated adenocarcinoma. Glicentin-immunoreactive cells could not be demonstrated either in tumor tissue or in nonneoplastic mucosa of the extrahepatic bile duct. With reference to the histogenesis of extrahepatic bile duct carcinoma, it was assumed from these results that the development of well-differentiated adenocarcinoma might be closely related to the occurrence of endocrine cells and that poorly differentiated adenocarcinoma might develop from ordinary mucosa.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Azadeh B, Parai SK (1980) Argentaffin cells, intestinal metaplasia and antral metaplasia in carcinoma of the gallbladder. Histopathology 4:653–659
Bergdahl L (1976) Carcinoid tumours of the biliary tract. Aust NZ J Surg 46:136–138
Christie AC (1954) Three cases illustrating the presence of argentaffin (Kultschitzky) cells in the human gall-bladder. J Clin Pathol 7:318–321
Delaquerriere L, Tremblay G, Riopelle J (1962) Argentaffine cells in chronic cholecystitis. Arch Pathol 74:142–151
Erspamer V (1936) Die enterochromaffinen Zellen der Gallenwege in normalen und pathologischen Zuständen. Nach Untersuchungen beim Menschen und bei Säugetieren. Virchows Arch [Pathol Anat] 297:70–92
Gerlock AJ, Muhletaler CA (1979) Primary common bile duct carcinoid. Gastrointest Radiol 4:263–264
Hospes K (1959) Über die argyrophile Cholecystitis. Virchows Arch [Pathol Anat] 332:236–244
Järvi O, Laurén P (1967) Intestinal metaplasia in the mucosa of the gallbladder and common bile duct. Ann Med Exp Fenn 45:213–223
Judge DM, Dickman PS, Trapukdi S (1976) Nonfunctioning argyrophil tumor (APUDoma) of the hepatic duct. Simplified methods of detecting biogenic amines in tissue. Am J Clin Pathol 66:40–45
Laitio M (1975) Goblet cells, enterochromaffin cells, superficial gastric-type epithelium and antral-type glands in the gallbladder. Beitr Pathol 156:343–358
Laitio M (1976) Early carcinoma of the gallbladder. Beitr Pathol 158:159–172
Laitio M (1980) Morphology and histochemistry of non-tumorous gallbladder epithelium. A series of 103 cases. Pathol Res Pract 167:335–345
Laitio M (1983a) Histogenesis of epithelial neoplasms of human gallbladder. I. Dysplasia. Pathol Res Pract 178:51–56
Laitio M (1983b) Histogenesis of epithelial neoplasms of human gallbladder. II. Classification of carcinoma on the basis of morphological features. Pathol Res Pract 178:57–66
Little JM; Gibson AAM, Kay AW (1968) Primary common bileduct carcinoid. Br J Surg 55:147–149
Sato H, Ohmura K, Mizushima M, Ito J, Yoshioka K (1982) Metaplastic endocrine cells in various diseases of the gallbladder. Jpn J Gastroenterol 79:2106–2111
Tahara E, Ito H, Nakagami K, Shimamoto F, Yamamoto M, Sumii K (1982) Scirrhous argyrophil cell carcinoma of the stomach with multiple production of polypeptide hormones, amine, CEA, lysozyme, and HCG. Cancer 49:1904–1915
Tsutsumi H, Nakura H, Osamura Y, Watanabe K, Yanaihara N (1982) Immunohistochemical study on the metaplastic change of gallbladder mucosa. In: Tsuchiya M (ed) Digestive organ and immunology, No. 9 (in Japanese) Ishiyaku-shuppan, Tokyo, pp 78–84
Van Steenbergen W, Fevery J, Vanstapel MJ, Geboes K, Ponette E, Kerremans R, De Groote J (1983) Case report: fourteen-year follow-up of an apudoma of the bile ducts at the hilum of the liver. Gastroenterol 84:1585–1591
Vitaux J, Salmon RJ, Languille O, Buffet C, Martin E, Chaput JC (1981) Carcinoid tumor of the common bile duct. Am J Gastroenterol 76:360–362
Yanaihara N (1980) Immunochemical application of synthetic peptides to studies on the prohormone-hormone system. Biomed Res 1:105–116
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamamoto, M., Takahashi, I., Iwamoto, T. et al. Endocrine cells in extrahepatic bile duct carcinoma. J Cancer Res Clin Oncol 108, 331–335 (1984). https://doi.org/10.1007/BF00390467
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00390467