Abstract
Direct toxicity of chemicals for components of the immune system may lead to altered host defence to infectious diseases. For this reason, it is important to screen for potential immunotoxicity. Screening can be best performed within the context of general toxicity screening, such as short term toxicity tests, subchronic toxicity testing, chronic toxicity testing or reproductive testing. General parameters of the immune system are useful to identify potential immunotoxicity. Confirmatory and more in depth information can be retrieved from functional studies. Such studies may include host infection models that have been proven to be very valuable for the process of risk evaluation.
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Van Loveren, H., Vos, J.G. Testing approaches to assess immunotoxicity of chemicals. Comp Haematol Int 6, 167–169 (1996). https://doi.org/10.1007/BF00368461
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DOI: https://doi.org/10.1007/BF00368461