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Proximal tubular reabsorption of some organic acids in the rat kidney in vivo

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Summary

Using a microperfusion technique proximal tubular reabsorption of sulfamerazine, phenobarbital, p-aminohippuric acid, uric acid, sulfaurea and N4-acetylsulfamerazine was studied as a function of intratubular pH in the rat kidney in vivo. Transtubular permeabilities were related to in vitro lipoid solubility measurements and degrees of non-dissociation of the acids. It was found that

  1. 1.

    sulfamerazine and phenobarbital exhibit nonionic backdiffusion, the magnitude of which is dependent on lipoid solubility,

  2. 2.

    p-aminohippuric acid, uric acid and sulfaurea do not show this backdiffusion, a finding explained by lack of lipoid solubility,

  3. 3.

    N4-acetylsulfamerazine, despite relatively high lipoid solubility, is not reabsorbed in the proximal tubule.

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Author notes

  1. Harald Sonnenberg

    Present address: Department of Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico

Authors and Affiliations

  1. Aus dem Physiologischen Institut der Freien Universität Berlin, Germany

    Harald Sonnenberg, Hellmut Oelert & Karl Baumann

Authors
  1. Harald Sonnenberg
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  2. Hellmut Oelert
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  3. Karl Baumann
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Additional information

With 2 Figures in the Text

Supported by NIH-Grant AM 06806-03 and the Deutsche Forschungsgemeinschaft.

Parts of this investigation have been reported at the meetings of the Deutsche Physiologische Gesellschaft, Bad Nauheim, 196419 and the American Physiological Society, Providence, 196420.

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Sonnenberg, H., Oelert, H. & Baumann, K. Proximal tubular reabsorption of some organic acids in the rat kidney in vivo. Pflügers Archiv 286, 171–180 (1965). https://doi.org/10.1007/BF00363859

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  • DOI: https://doi.org/10.1007/BF00363859

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