Abstract
The usefulness of radioimmunoguided endoscopy in the detection of primary and recurrent rectal cancer was investigated. Of the 15 patients included in our study, 4 with suspected primary rectal cancer were examined preoperatively, while the remaining 11 were studied after radical resection of rectal carcinoma with the aim of detecting local recurrence. Radioimmunoguided endoscopy was performed employing a hand-held gamma-detecting probe (mod. 2 Oris, France), after the administration of a 111In labeled monoclonal antibody to CEA. Radioimmuno-guided endoscopy results detected the presence of primary or recurrent periluminal cancer in seven cases. In four it modified the preoperative stage based on the findings of conventional investigation and it influenced the surgical decision in five cases. No toxicity was noted and none of the patients developed HAMAs.
Résumé
L'utilité de l'endoscopie radioimmuno-guidée dans la détection des cancers primaires ou récidivants a été étudiée. Des 15 malades inclus dans notre étude, 4 suspects de cancer rectal primaire ont été examinés pré-opératoirement, tandis que les 11 restants fûrent étudiés après résection radicale d'un cancer rectal dans le but de déceler une récurrence. L'endoscopie radioimmuno-guidée fût faite en utilisant une sonde manuelle détectant les rayons gamma (mod. 2 Oris France) après l'administration d'un anticorps monoclonal à l'ACE marqué avec In 111. L'endoscopie radioimmuno-guidée a permis de détecter la présence de cancers primaires ou récidivants péri-rectaux dans 7 cas. Chez 4 patients ceci a permis de modifier le stage pré-opératoire basé sur les découvertes de l'investigation conventionnelle et a influencé la décision chirurgicale chez 4 malades. Il n'y eu pas de toxicité et aucun de nos patients n'a développé HAMAS.
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Prati, U., Roveda, L., Butera, R. et al. Radioimmuno-guided endoscopy (RIGE) in the detection of primary and recurrent rectal tumor. Int J Colorect Dis 7, 155–158 (1992). https://doi.org/10.1007/BF00360357
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DOI: https://doi.org/10.1007/BF00360357