Abstract
A pharmacokinetic study of ampicillin (6 mg/kg intravenous) revealed that the peak concentrations of 17.81±1.25, 5.64±2.24 and 1.09±0.10 μg/ml of the drug were attained at 15 min, 30 min and 2 h in plasma, milk and uterine fluid respectively. A therapeutic concentration of ≥0.1 μg/ml was maintained from 15 min–8 h, 15 min–6 h and 30 min–6 h in plasma, milk and uterine fluid. Hence, the drug may be used effectively in mammary gland and uterine infections apart from its use in other systemic infections.
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Jayachandran, C., Singh, M.K. & Banerjee, N.C. Pharmacokinetics and distribution of ampicillin in plasma, milk and uterine fluid of female buffaloes. Veterinary Research Communications 14, 47–51 (1990). https://doi.org/10.1007/BF00346383
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DOI: https://doi.org/10.1007/BF00346383