Summary
We carried out a study on 63 patients suffering from alcoholism in order to determine the frequency of 27 HLA antigens. In comparison to healthy blood donors no significant deviation of HLA distributions in alcoholics was found. The data on alcoholic patients with physical consequences such as cerebral seizures, liver cirrhosis and polyneuropathy failed to identify an assocation with HLA.
Zusammenfassung
In einer Populationsuntersuchung mit 63 Alkoholikern wurden 27 HLA Antigene hinsichtlich ihres Auftretens bestimmt. Im Vergleich zu gesunden Blutspendern ergaben sich keine signifikanten Differenzen der Antigenfrequenzen. Es konnten keine Assoziationen zwischen HLA und Alkoholkrankheit aufgedeckt werden. Im Verlauf von Alkoholismus auftretende Komplikationen wie Krampfanfälle, Leberzirrhose und Polyneuropathie waren nicht mit HLA assoziiert.
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References
Camps F, Dodd B (1967) Increase in the incidence of nonsecretors of ABH blood group substances among alcoholic patients. Br Med J 1:30–31
Camps F, Dodd B, Lincoln P (1969) Frequencies of secretors and nonsecretors of ABH group substances among 1,000 alcoholic patients. Br Med J 4:457–459
Cruz-Coke R (1964) Color-blindness and cirrhosis of the liver. Lancet: 1064–1065
Cruz-Coke R, Varela A (1966) Inheritance of alcoholism. Lancet: 1282
Diagnostic and Statistical Manual of Mental Disorders, 3rd edn, American Psychiatric Association 1980
Fialkow P, Thuline H, Fenster LF (1966) Lack of association between cirrhosis and the common types of color blindness. N Engl Med 275:584–587
Giannitsis D, Rösler M, Bellaire W, Jarovici A, Braun S (1982) HLA-antigens and schizophrenia. Blut 45:68
Goodwin DW (1982) Familial alcoholism. In: Perris C, Struwe G, Jansen B (eds) Biological psychiatry 1981. Elsevier/North Holland Biomedical Press, Amsterdam New York Oxford, pp 936–940
Goodwin DW, Guze SB (1974) Heredity and alcoholism. In: Kissin B, Begleiter H (eds) The biology of alcoholism. Plenum Press, New York London
Gorrell GJ (1967) Inheritance of alcoholism. Lancet: 274
Hill SY, Goodwin W, Cadoret R, Osterland CK, Doners SM (1975) Association and linkage between alcoholism and eleven serological markers. J Stud Alcohol 36:981–992
Rösler M, Bellaire W, Giannitsis D, Jarovici A, Greß H (1982) Zusammenhang zwischen HLA-Antigenen und schizophrenen Syndromen. Psycho Supplement 1:70–71
Rösler M, Bellaire W, Gressnich N, Giannitsis D, Jarovici A (1983) HLA-Antigens in schizophrenia, major depressive disorder and schizoaffective disorder. Med Microbiol Immunol 172:57–65
Svejgaard A, Platz P, Ryder LP, Nielsen LS, Thomsen N (1975) HL-A and disease associations — A survey. Transplant Rev 22:3–43
Swinson RP, Madden JS (1973) ABO blood groups and ABH substance secretion in alcoholics. J Stud Alcohol 34:64–70
Terasaki P, McClelland J (1964): Microdroplet assay of human serum cytotoxins. Nature 204:998–1000
Thuline HC (1967) Inheritance of alcoholism. Lancet: 274–275
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Rösler, M., Bellaire, W., Hengesch, G. et al. Genetic markers in alcoholism: No association with HLA. Arch Psychiatr Nervenkr 233, 327–331 (1983). https://doi.org/10.1007/BF00345801
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DOI: https://doi.org/10.1007/BF00345801