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Effects of angiographic contrast media on regional cerebral blood flow and haemodynamics in man

Les effets des produits de contraste angiographiques sur le flux sanguin cérébral régional chez l'homme

Der Einfluß von Röntgenkontrastmitteln bei der cerebralen Angiographie auf die regionale Hirndurchblutung und Kreislauffunktion des Menschen

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Summary

In 33 human subjects with a sound circulatory system regional cerebral blood flow changes, following intracarotid injection of sodium methylglucamine diatrizoate (Angiografin, Urografin 76%) during cerebral angiography, were investigated. Angiografin®, at the start of recording 1 and 3 min after intracarotid injection, caused an increase of rCBF of 15.7% and 7.8% respectively. Urografin®, 3 min after completion of intracarotid injection, brought about an increase of rCBF of 23.0%. Under the action of both X-ray radiopaque materials at the start of rCBF-measurement, 5 and 8 min after completed intracarotid injection, there no longer was a significant difference from the resting values. Changes in haemodynamics (blood pressure, pulse rate) during carotid cerebral angiography with sodium-methylglucamine diatrizoate (Angiografin, Urografin 76%) were not observed in this study.

Résumé

Chez 33 sujets humains avec un système cireulatoire régional normal, les auteurs ont étudié les répercussions de l'injection intra-carotidienne du sodium méthylglucamine diatrizoate (Angiografine, Urografine 76%) sur le flux sanguin cérébral régional au cours de l'angiographie cérébrale. Dans le cas de l'Angiografine, on notait une augmentation du flux sanguin cérébral régional de 15.7% et 7.8% respectivement 1 et 3 min après l'injection intra-carotidienne. Avec l'Urografine 76%, l'augmentation du flux sanguin cérébral régional était de 23.0%. Les mesures pratiquées 5 et 8 min après la fin de l'injection ne montraient pas de différence sensible entre les deux produits de contraste. Chez ces malades il n'y a pas eu de modifications hémodynamiques (pression sanguine, pouls) sous l'influence du sodium méthylglucamine diatrizoate (Angiografine, Urografine 76%) au cours de l'angiographie carotidienne.

Zusammenfassung

Bei 33 kreislaufgesunden Patienten wurden die Veränderungen der regionalen Hirndurchblutung nach Injektion von Angiografin bzw. Urografin 76% in die A. carotis interna untersucht. Dabei fand sich nach Angiografin bei Beginn der Durchblutungs-messung im zeitlichen Abstand von 1 bzw. 3 Min. nach erfolgter Injektion des Kontrastmittels eine Zunahme des rCBF um 15,7% bzw. 7,8%. Urografin rief bei Meßbeginn im zeitlichen Abstand von 3 Min. nach erfolgter Injektion des Kontrastmittels einen rCBF-Anstieg von 23% hervor. Bei Meßbeginn im zeitlichen Abstand von 5 und 8 Min. nach der Injektion war eine signifikante Differenz von der Ausgangslage nicht mehr erkennbar. Die Verfasser konnten keine Veränderungen der Kreislaufparameter (Blutdruck, Pulsfrequenz) während der Angiographie feststellen.

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Authors and Affiliations

  1. Department of Neurology (Division of Neuroradiology) and Department of Department of Anaesthesiology, Akademisches Krankenhaus Nordwest, Johann Wolfgang-Goethe-Universität Frankfurt a. M., Germany (FRG)

    H. Herrschaft, F. Gleim & H. Schmidt

  2. Krankenhaus Nordwest Neurologische Klinik, Steinbacher Hohl 2-26, D-6000, Frankfurt a. M. 90, Federal Republic of Germany

    H. Herrschaft

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  2. F. Gleim
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  3. H. Schmidt
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Herrschaft, H., Gleim, F. & Schmidt, H. Effects of angiographic contrast media on regional cerebral blood flow and haemodynamics in man. Neuroradiology 7, 95–103 (1974). https://doi.org/10.1007/BF00341877

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