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An extended first approximation model for the amygdaloid kindling phenomenon

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Abstract

A first approximation model, which accounts for the strongest phenomena defining kindling is suggested. It is based on an excitatory-inhibitory coupling of neural aggregates, to which a self-stimulation element for the excitatory aggregate was added. The functional linking hypothesis views the representation of kindling as a process of gradual transition through structural changes from a stable system to a system showing stability for small perturbations and an oscillatory orbit for larger perturbations, to a purely oscillatory system. The anatomical linking hypothesis views the excitatory aggregate as representing the hypothalamus, the inhibitory aggregate as representing the hippocampal-septal-preoptic complex, and the selfstimulating element of the excitatory aggregate as representing the amygdaloid-pyriform complex. The model was realized on a digital computer with graphic capabilities and showed good qualitative agreement with the experimental data related to kindling. In addition, the use of the model for generating new experiments is discussed.

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Authors and Affiliations

  1. Center for Systems Neuroscience, University of Massachusetts at Amherst, Amherst, Mass., USA

    I. Lieblich & S. Amari

  2. Dept. of Psychology, The Hebrew University of Jerusalem, Jerusalem, Israel

    I. Lieblich

Authors
  1. I. Lieblich
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  2. S. Amari
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Lieblich, I., Amari, S. An extended first approximation model for the amygdaloid kindling phenomenon. Biol. Cybernetics 28, 129–135 (1978). https://doi.org/10.1007/BF00337134

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  • DOI: https://doi.org/10.1007/BF00337134

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