Summary
Strong, elastic clots are required for the removal of renal calculi by coagulum pyelolithotomy. An in vitro study was performed to establish the optimal conditions for the formation of clots. A thrombelastograph was used to measure the clotting time and elasticity. For tensile strength measurements, a special apparatus was constructed. The use of platelet-rich plasma as a source of fibrinogen resulted in weak clots. Cryoprecipitate proved to furnish good clots, especially when clotting was induced by calcium. The addition of thrombin had an adverse effect on the strength and elasticity of the clot. In our hands, optimal clots were obtained by mixing 15 ml of regular bloodbank cryoprecipitate with 1 ml of 10% calcium laevulate or 0.5 ml of 10% calcium chloride at room temperature and waiting for a period of 10 min. Preheating to 37°C offered no advantage and a limited degree of dilution with urine had no adverse effect on the clot properties. Clot particles dissolve in urine within 1.5 days.
Similar content being viewed by others
References
Dees JE (1943) The use of an intrapelvic coagulum in pyelolithotomy. South Med J 36:167
Hartert H (1952) Klinische Blutgerinnungsstudien mit der Thrombelastographie. Dtsch Archiv fklinische Medizin 199:284
Kalash SS, Young JD Jr, Harne G (1982) Modification of cryoprecipitate coagulum pyelolithotomy technique. Urology 19:467
Marshall S (1978) Commercial fibrinogen, autogenous plasma, whole blood and cryoprecipitate for coagulum pyelolithotomy: a comparative study. J Urol 119:310
Patel VJ (1983) The technique, results and complications of coagulum pyelolithotomy, a report of 450 cases. AUA Meeting, Las Vegas
Pence JR (1981) Editorial comment. J Urol 126:435
Pool JG, Shannon AE (1965) Production of high potency concentrates of antihemophilic globulin in a closed-bag system. N Engl J Med 273:1443
Vreeken J (1957) Trombelastografie. Diss Amsterdam
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Lycklama à Nijeholt, A.A.B., Briët, E. & Jonas, U. Coagulum pyelolithotomy: the determination of optimal conditions for clot formation. World J Urol 4, 119–121 (1986). https://doi.org/10.1007/BF00326405
Issue Date:
DOI: https://doi.org/10.1007/BF00326405