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Simultaneous spectrophotometric determination of fat-soluble vitamins in multivitamin pharmaceutical preparations

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  • Pharmaceutical Analysis
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Abstract

A spectrophotometric method is proposed for the simultaneous determination of vitamins A, D and E in multivitamin pharmaceutical preparations. This is based on multiple linear regression. Most vitamins are directly extracted from the preparations into n-hexane. Microen-capsulated vitamin A preparations require pretreatment of de-encapsulation before the vitamin is extracted. The wavelength range to be used for each preparation and the optimum spectral mode (absorbance or first-derivative) has been chosen in order to assure correct quantitation and avoid interferences from other absorbing species also extracted by n-hexane. The results obtained were validated by simultaneous HPLC analyses for accuracy and precision.

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Authors and Affiliations

  1. Departamento de Química, Unidad de Química Analítica, Universidad Autónoma de Barcelona, E-08193, Bellaterra, Barcelona, Spain

    M. Blanco, J. Coello, H. Iturriaga, S. Maspoch, T. Gómez-Cotín, S. Alaoui-Ismaili & E. Rovira

Authors
  1. M. Blanco
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  2. J. Coello
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  3. H. Iturriaga
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  4. S. Maspoch
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  5. T. Gómez-Cotín
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  6. S. Alaoui-Ismaili
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  7. E. Rovira
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Blanco, M., Coello, J., Iturriaga, H. et al. Simultaneous spectrophotometric determination of fat-soluble vitamins in multivitamin pharmaceutical preparations. Fresenius J Anal Chem 351, 315–319 (1995). https://doi.org/10.1007/BF00321656

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  • DOI: https://doi.org/10.1007/BF00321656

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