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Hairy cell leukemia: A B-lymphocytic disorder derived from splenic marginal zone lymphocytes?

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Summary

Although there is increasing evidence that the majority of cases of hairy cell leukemia represent B-lymphoproliferative disorders, the exact subset of B-cells from which hairy cells are derived, is still unclear. On the basis of results obtained in previous studies, and data collected from the literature, it is suggested that B-lymphocytes normally residing in the marginal zone of the splenic white pulp (so called ‘marginal zone lymphocytes’) represent the cell type from which B-lineage derived hairy cells originate.

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References

  1. Alexander E, Sanders S (1978) Fc receptor bearing ‘hairy cells’ of leukaemic reticuloendotheliosis bind soluble antigen-antibody complexes and adhere to immobilized complexes, but fail to mediate antibody dependant cellular cytotoxicity. Scand J Immunol 8: 477–488

    Google Scholar 

  2. Alptuna E, Anteunis A, Krulik M, Astesano A, Ronbineaux R, Debray J (1978) Hairy cell leukemia: A clinical, immunological and ultrastructural study. Virchows Arch (Cell Pathol) 28: 135–149

    Google Scholar 

  3. Budman DR, Koziner B, Arlin Z, Lampen N, Gee T (1979) Massive lymphadenopathy mimicking lymphoma in leukemic reticuloendotheliosis. Am J Med 66: 160–162

    Google Scholar 

  4. Burns GF, Cawley JC (1979) A re-examination of the alleged monocytic features of hairy-cell leukaemia. Scand J Haematol 22: 386–396

    Google Scholar 

  5. Catovsky D, Frisch B, Okos A, Van Noorden S (1975) Scanning electron microscopy and the nature of the hairy cell (letter). Lancet I: 462–463

    Google Scholar 

  6. Cohen HJ, George ER, Kremer WB (1979) Hairy cell leukemia: cellular characteristics including surface Immunoglobulin dynamics and biosynthesis. Blood 53: 764–775

    Google Scholar 

  7. Davis TE, Waterbury L, Abeloff M, Burke PJ (1976) Leukemic reticuloendotheliosis. Report of a case with prolonged remission following intensive chemotherapy. Arch Intern Med 136: 620–622

    Google Scholar 

  8. Dobashi M, Terashima K, Imai Y (1982) Electron microscopic study of differentiation of antibody-producing cells in mouse lymph nodes after immunization with horseradish peroxidase. J Histochem Cytochem 30: 67–74

    Google Scholar 

  9. Gransar A, Sheibani K, Barna BP, Savage RA, Valenzuela R, McMahon JT, Deodhar SD (1983) Characterization of blood mononuclear and cultured cells in hairy cell leukemia. Am J Clin Pathol 79: 733–737

    Google Scholar 

  10. Hsu S-M, Yang K, Jaffe ES (1983) Hairy cell leukemia: A B cell neoplasm with a unique antigenic phenotype. Am J Clin Pathol 80: 421–428

    Google Scholar 

  11. Jaffe ES, Shevach EM, Sussman EH, Frank M, Green I, Berard CW (1975) Membrane receptor sites for the identification of lymphoreticular cells in benign and malignant conditions. Br J Cancer 31 (Suppl II): 107–120

    Google Scholar 

  12. Jansen J, Schuit HRE, van Zwet ThL, Leijer CJLM, Hijmans W (1979) Hairy-cell leukaemia. A B-lymphocytic disorder. Br J Haematol 42: 21–33

    Google Scholar 

  13. Katayama I, Li CY, Yam LT (1972) Ultrastructural characteristics of the “hairy cells” of leukemic reticuloendotheliosis. Am J Pathol 86: 361–370

    Google Scholar 

  14. Kumararatne DS, Bazin H, MacLennan ICM (1981) Marginal zones: the major B cell compartment of rat spleens. Eur J Immunol 11: 858–864

    Google Scholar 

  15. Kumararatne DS, MacLennan ICM (1981) Cells of the marginal zone of the spleen are lymphocytes derived from recirculating precursors. Eur J Immunol 11: 865–869

    Google Scholar 

  16. Layton JE, Baker J, Bartlett PF, Shortman K (1981) Antigen-initiated B lymphocate differentiation. XVIII. Pre-progenitor B cells that give primary adoptive responses are s-IgM+IgD−Ia+. J Immunol 126: 1227–1233

    Google Scholar 

  17. Lennert K (1978) Malignant lymphomas other than Hodgkin's disease. Histology, cytology, ultrastructure, immunology. Springer, Berlin Heidelberg New York

    Google Scholar 

  18. Meijer CJLM, Albeda F, Van der Valk P, Spaander PJ, Jansen J (1984) Immunohistochemical studies of the spleen in hairy-cell leukemia. Am J Pathol 115: 266–274

    Google Scholar 

  19. Mitchell J, Abbot A (1971) Antigens in immunity. XVI. A light and electron microscope study of antigen localization in the rat spleen. Immunology 21, 207–224

    Google Scholar 

  20. Palutke M, Weise RW, Tabaczka P, Varadachari C, Axelrod A (1978) Hairy cells and macrophages. A comparative study. Lab Invest 39: 267–280

    Google Scholar 

  21. Rosner MC, Golomb HM (1980) Ribosoma-lamellae complex in hairy-cell leukemia: ultrastructure and distribution. Lab Invest 42: 236–247

    Google Scholar 

  22. Salsano F, Pisarri-Salsano S, Ciancarelli MP, Piantelli M, Lauriola L, Musiani P (1979) Structural and functional characteristics of hairy cells. Acta Haematol 61: 184–193

    Google Scholar 

  23. Sasou S, Satodate R, Suzuki A (1980) A scanning electron microscopic study of the perifollicular region of the rat spleen. J Reticuloend Soc 27: 461–469

    Google Scholar 

  24. Slease RB, Gadek JE, Frank MM, Scher I (1980) Distribution of complement receptors on human normal and malignant mononuclear cells. Blood 56: 792–797

    Google Scholar 

  25. Stein H, Bonk A, Tolksdorf G, Lennert K, Rodt H, Gerdes J (1980) Immunohistologic analysis of the organization of normal lymphoid tissue and Non-Hodgkin's lymphomas. J Histochem Cytochem 28: 746–760

    Google Scholar 

  26. Tolksdorf G, Stein H (1979) Acid alpha-napthyl acetate esterase in hairy cell leukemia cells and other cells of the hematopoietic system. Blut 39: 165–176

    Google Scholar 

  27. Tubbs RR, Savage RA, Sebek BA, Fishleder A, Weick JK (1984) Antigenic phenotype of splenic hairy cells. Am J Med 76: 199–205

    Google Scholar 

  28. Turner A, Kjeldberg CR (1978) Hairy-cell leukemia: A review. Medicine 57: 477–499

    Google Scholar 

  29. Van den Oord JJ, De Wolf-Peeters C, De Vos R, Desmet VJ (1984) Immature sinushistiocytosis. Light- and electronmicroscopic features, immunological phenotype and relationship with marginal zone lymphocytes. Am J Pathol (in press)

  30. Van den Oord JJ, De Wolf-Peeters C, De Vos R, Desmet VJ (1984) On the origin of “monocytoid” cells in reactive lymph nodes (letter). Am J Clin Pathol 82: 511

    Google Scholar 

  31. Van der Valk P, van der Loo EM, Jansen J, Daha MR, Meijer CJLM (1984) Analysis of lymphoid and dendritric cells in human lymph node, tonsil and spleen. A study using monoclonal and heterologous antibodies. Virchows Arch (Cell Pathol) 45: 169–185

    Google Scholar 

  32. Van Rooijen N (1973) Mechanism of follicular antigen trapping. Migration of antigen-antibody complexes from marginal zone towards follicle centres. Immunology 25: 847–852

    Google Scholar 

  33. Veerman AJP, van Ewijk W (1975) White pulp compartments in the spleen of rats and mice. A light and electron microscopic study of lymphoid and non-lymphoid celltypes in T- and B-areas. Cell Tiss Res 156: 417–441

    Google Scholar 

  34. Veerman AJP, van Rooijen N (1975) Lymphocyte capping and lymphocyte migration as associated events in the in vivo antigen trapping process. An electron-microscopic autoradiographic study in the spleen of mice. Cell Tiss Res 161: 211–217

    Google Scholar 

  35. Veldman JE, Keuning FJ, Molenaar I (1978) Site of initiation of the plasma cell reaction in the rabbit lymph node. Ultrastructural evidence for two distinct antibody forming cell precursors. Virchows Arch (Cell Pathol) 28: 187–202

    Google Scholar 

  36. Yam LT, Li CY, Lam KW (1971) Tartrate-resistant acid phosphatase isoenzymes in the reticulum cells of leukemic reticuloendotheliosis. N Engl J Med 284: 357–360

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Laboratorium voor Histo- en Cytochemie, Academisch Ziekenhuis St. Rafael, Catholic University of Leuven, B-3000, Leuven, Belgium

    J. J. van den Oord, C. de Wolf-Peeters & V. J. Desmet

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  1. J. J. van den Oord
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  2. C. de Wolf-Peeters
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  3. V. J. Desmet
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van den Oord, J.J., de Wolf-Peeters, C. & Desmet, V.J. Hairy cell leukemia: A B-lymphocytic disorder derived from splenic marginal zone lymphocytes?. Blut 50, 191–194 (1985). https://doi.org/10.1007/BF00320293

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