Summary
The development of acute lymphoblastic leukemia (c-ALL) in identical twins is reported. The first born had ALL in 1982 and bone marrow transplantation was performed in first complete remission (CR) from his healthy twin-brother the same year. The bone marrow donor developed ALL in 1985; he received an autologous bone marrow transplantation in first CR in 1986. Unfortunately, both patients relapsed in 1986. Cytogenetic studies of the first born revealed multiple chromosomal abnormalities and a marker chromosome whereas the second patient had a Philadelphia chromosome. Genetic reasons or exposure to leukemogenic agents may be responsible for the onset of these leukemias.
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Hecht, T., Henke, M., Schempp, W. et al. Acute lymphblastic leukemia in adult identical twins. Blut 56, 261–264 (1988). https://doi.org/10.1007/BF00320286
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DOI: https://doi.org/10.1007/BF00320286