Summary
A new semidominant mutation in the laboratory mouse, Dickie's small eye (Dey), is described. It is localized on chromosome 2. Heterozygotes show reduced body size, small eyes with coloboma, small or lacking lens with cataract, abnormal folding of the retina and reduction of the pigment layer. The anterior chamber is usually missing. Homozygotes apparently die early in pregnancy.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Searle, A.G.: New mutants, 2: Coloboma. Mouse News Letter 35, 27 (1966)
Varnum, D.S., Stevens, L.C.: Linkage data, 4: Dickie's small eye. Mouse News Letter 57, 21 (1977)
Theiler, K., Varnum, D.S., Nadeau, J.H., Stevens, L.C., Cagianut, B.: A new allele of ocular retardation: Early development and morphogenetic cell death. Anat. Embryol. 150, 85–96 (1976)
Author information
Authors and Affiliations
Additional information
This work was supported by Research Grant CA 02662 from the National Cancer Institute, and by Research Grant NS 09378 from The National Institute of Neurological Diseases and Stroke
The Jackson Laboratory is fully accredited by The American Association for Accreditation of Laboratory Animal Care
Rights and permissions
About this article
Cite this article
Theiler, K., Varnum, D.S. & Stevens, L.C. Development of Dickie's small eye, a mutation in the house mouse. Anat Embryol 155, 81–86 (1979). https://doi.org/10.1007/BF00315732
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00315732