Summary
The role of dopamine synthesis in the renal actions of human α-atrial natriuretic peptide (αANP) was investigated in six dehydrated volunteers using the DOPA decarboxylase inhibitor carbidopa.
Each subject received oral placebo or carbidopa (100 mg) followed by an infusion of αANP 10 pmol · kg−1 · min−1 for 1 h. The responses to placebo alone and to carbidopa alone were investigated on separate occasions. αANP produced a similar increase in plasma immunoreactive αANP whether placebo or carbidopa pretreatment had been given. Urinary dopamine excretion was increased by αANP. Carbidopa pretreatment substantially attenuated this increase without affecting the natriuretic or water-diuretic response to αANP. Carbidopa also failed to alter the change in filtration fraction produced by αANP.
The results suggest that increased synthesis of intrarenal dopamine is not required for the renal effects of αANP in man.
Similar content being viewed by others
References
Goldberg LI (1972) Cardiovascular and renal actions of dopamine: potential clinical applications. Pharmacol Rev 24: 1–29
Lee MR (1982) Dopamine and the kidney. Clin Sci 62: 439–448
Ballermann BJ, Brenner BM (1985) Biologically active atrial peptides. J Clin Invest 76: 2041–2048
Alexander RW, Gill JR, Yamabe H, Lovenberg W, Keiser HR (1974) Effects of dietary sodium and of acute saline infusion on the interrelationship between dopamine excretion and adrenergic activity in man. J Clin Invest 54: 194–200
Sowers JR, Crane PD, Beck FWJ, McClanahan M, King ME, Mohanty PK (1984) Relationship between urinary dopamine production and natriuresis after intravascular volume expansion with sodium chloride in dogs. Endocrinology 115: 2085–2090
McClanahan M, Sowers JR, Beck FWJ, Mohanty PK, McKenzie T (1985) Dopaminergic regulation of natriuretic response to acute volume expansion in dogs. Clin Sci 68: 263–269
Marin-Grez M, Briggs JP, Schubert G, Schnermann J (1985) Dopaminergic receptor antagonists inhibit the natriuretic response to atrial natriuretic factor (ANF). Life Sci 36: 2171–2176
Petterson A, Hedner J, Hedner T (1986) The diuretic effect of atrial natriuretic peptide (ANP) is dependent on dopaminergic activation. Acta Physiol Scand 126: 619–621
Webb RL, Della Puca R, Manniello J, Robson RD, Zimmermann MB, Ghai RD (1986) Dopaminergic mediation of the diuretic and natriuretic effects of ANF in the rat. Life Sci 38: 2319–2327
Hansell P, Fasching A, Sjoquist M, Anden NE, Ulfendahl HR (1987) The dopamine receptor antagonist haloperidol blocks natriuretic but not hypotensive effects of the atrial natriuretic factor. Acta Physiol Scand 130: 401–407
Murphy MB, Bass AS, Goldberg LI (1988) Renal effects of atrial natriuretic factor are independent of dopamine 1 receptors. Am J Physiol 255: F494-F499
Pettersson A, Hedner J, Hedner T (1989) Relationship between renal sympathetic activity and diuretic effects of atrial natriuretic peptide (ANP) in the rat. Acta Physiol Scand 135: 323–333
Wilkins MR, Kendall MJ, Lote CJ, West MJ, Wood JA (1986) Partial attenuation of the renal response to high-dose infusion of atrial natriuretic peptide by carbidopa. J Hypertens 4 [Suppl 5]: S83-S85
Freestone S, MacDonald TM, Jeffrey RF, Brown J, Lee MR (1989) The renal effects of atrial natriuretic peptide in man are not attenuated by (+)-sulpiride. Br J Clin Pharmacol 27: 13–18
Schreiner GE (1950) Determination of inulin by means of resorcinol. Proc Soc Exp Biol Med 74: 117–120
Smith HW, Finkelstein N, Aliminosa L, Crawford B, Graber M (1945) The renal clearance of substituted hippuric acid derivatives and other aromatic acids in dog and man. J Clin Invest 24: 388–404
O'Flynn M, Causon R, Brown J, Kageyama S (1988) Development of a solid phase extraction technique for α-human atrial natriuretic peptide (α-hANP) in human plasma. J Chromatogr 452: 469–476
Brown M, Jenner DA (1981) Novel double-isotope technique for enzymatic assay of catecholamine, permitting high precision, sensitivity and plasma sample capacity. Clin Sci 61: 591–598
Cody RJ, Atlas SA, Laragh JH, Kudo SH, Covit AB, Ryman KS, Shaknovich A, Pondolfino K, Clark M, Camargo MJF, Scarborough RM, Lewicki JA (1986) Atrial natriuretic factor in normal subjects and heart failure patients. J Clin Invest 78: 1362–1374
Weidmann P, Hasler H, Gnadinger MP, Lang RE, Uehlinger DE, Shaw S, Rascher W, Reubi FC (1986) Blood levels and renal effects of atrial natriuretic peptide in normal man. J Clin Invest 77: 734–742
Anderson JV, Struthers AD, Christofides N, Bloom SR (1986) Atrial natriuretic peptide: an endogenous factor enhancing sodium excretion in man. Clin Sci 70: 327–331
Brown J, Corr L (1987) Renal mechanisms of human α-atrial natriuretic peptide in man. J Physiol (London) 387: 31–46
Ball SG, Gunn IG, Douglas IHS (1982) Renal handling of dopa, dopamine, norepinephrine and epinephrine in the dog. Am J Physiol 242: F56-F62
Struthers AD, Anderson JV, Payne N, Causon RC, Slater JDH, Bloom SR (1986) The effect of atrial natriuretic peptide on plasma renin activity, plasma aldosterone and urinary dopamine in man. Eur J Clin Pharmacol 31: 223–226
Jeffrey RF, MacDonald TM, Rutter M, Freestone S, Bronw J, Samson RR, Lee MR (1987) The effect of intravenous frusemide on urine dopamine in normal volunteers: studies with indomethacin and carbidopa. Clin Sci 73: 151–157
Ullrich KJ, Rumrick G, Kloss S (1974) Sodium dependence of the amino-acid transport in the proximal convolution of the rat kidney. Pflügers Arch 351: 49–60
Frederickson ED, Bradley T, Goldberg LI (1985) Blockade of renal effects of dopamine in the dog by the DA1 antagonist, SCH-23390. Am J Physiol 249: F236-F240
Kastner PR, Ertel MA, Bohnke RA, Emmert LW, Burkhard TA (1987) Dopamine (DA1) receptor blockade does not inhibit the diuretic/natriuretic (D/N) effects of [Ile12] 5–28 atrial natriuretic peptide (ANP) in rhesus monkeys. Fed Proc 46: 1296 (Abstract)
McMurray JJ, Seidelin PH, Brown RA, Struthers AD (1989) Noradrenaline attenuates the natriuretic effect of atrial natriuretic factor in man. Br J Clin Pharmacol 27: 7–12
Allen MJ, Ang VTY, Bennet ED (1988) Domperidone, a DA2-specific dopamine antagonist, has no effect on the renal or haemodynamic response to atrial natriuretic peptide in man. Clin Sci 75: 569–575
Katoh T, Matsunaga H, Ohnuma N, Kurokawa K (1986) Renal effects of atrial natriuretic peptide (ANP) may be mediated by dopamine in the rat. Kidney Int 29: 336 (Abstract)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kageyama, S., Brown, J., Causon, R. et al. DOPA decarboxylase inhibition does not influence the diuretic and natriuretic response to exogenous α-atrial natriuretic peptide in man. Eur J Clin Pharmacol 38, 223–227 (1990). https://doi.org/10.1007/BF00315020
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00315020