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Investigation of a possible pharmacokinetic interaction between ibopamine and isosorbide-5-mononitrate

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Summary

The possibility of a pharmacokinetic interaction between isosorbide-5-mononitrate (5-ISMN) and epinine, the active metabolite of ibopamine, has been investigated in 8 healthy male subjects given single doses of 200 mg ibopamine and 20 mg 5-ISMN, separately and together.

The plasma 5-ISMN concentration-time profile was the same whether 5-ISMN was administered concomitantly with ibopamine or alone [AUC(o-t): 2.24 μg·ml−1·h after 5-ISMN alone, 2.16 μg·ml−1·h after 5-ISMN + ibopamine]. The plasma concentrations of total and free epinine and the urinary recovery of total epinine, homovanillic acid and dihydroxyphenylacetic acid, too, were not different when ibopamine was administered alone or concomitantly with 5-ISMN. The intake of ibopamine did not change the blood pressure and heart rate. The decrease in diastolic blood pressure induced by 5-ISMN was not influenced by concomitant intake of ibopamine.

The observations suggest that in healthy volunteers there is no pharmacokinetic interaction between 5-ISMN and ibopamine.

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References

  • Abrams J (1980) Nitroglycerin and long-acting nitrates. N Engl J Med 302: 1234–1237

    Google Scholar 

  • Azzollini F, De Caro L, Longo A, Pelosi G, Rolandi E, Ventresca GP, Lodola E (1988) Ibopamine kinetics after single and multiple dosing in patients with congestive heart failure. Int J Clin Pharmacol Ther Tox 26: 544–551

    Google Scholar 

  • Dei Cas L, Manca C, Vasini G, Mansour M, Bernardini B, Visioli O (1980) Non-invasive evaluation of left ventricular function through systolic time intervals following oral administration of SB 7505 in man. Drug Res 30: 498–500

    Google Scholar 

  • Henwood JM, Todd PA (1988) Ibopamine, a preliminary review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy. Drugs 36: 11–31

    Google Scholar 

  • Lodola E, Borgia M, Longo A, Pocchiari F, Pataccini R, Sher D (1986) Ibopamine kinetics after a single oral dose in healthy volunteers. Drug Res 36: 345–348

    Google Scholar 

  • Longhini C, Musacci GF, Ansani L, Toselli T, Artiolli T, Bianco L, Ghirardi P (1983) Effect of ibopamine on peripheral haemodynamics. Eur J Clin Pharmacol 24: 585–589

    Google Scholar 

  • Major RM, Taylor T, Chasseaud LF, Darragh A, Lambe RF (1984) Isosorbide 5-mononitrate kinetics. Clin Pharmacol Ther 35: 653–659

    Google Scholar 

  • Ochs HR, Neugebauer G, Greenblatt DJ, Labedzki L (1986) Influence of beta-blocker coadministration on the kinetics of isosorbide mononitrate and dinitrate. Klin Wochenschr 64: 1213–1216

    Google Scholar 

  • Packer M (1983) New perspectives on therapeutic application of nitrates and vasodilator agents for severe chronic heart failure. Am J Med 74: 61–72

    Google Scholar 

  • Pocchiari F, Pataccini R, Castelnovo P, Longo A, Casagrande C (1986) Ibopamine, an orally active dopamine-like drug: metabolism and pharmacokinetics in rats. Drug Res 36: 334–340

    Google Scholar 

  • Rosseel MT, Bogaert MG (1979) Simultaneous determination of isosorbide dinitrate and its mononitrates in human plasma by capillary column GLC. J Pharm Sci 68: 659–660

    Google Scholar 

  • Scott SC, Locke-Haydon J, Pready NS, Buller NP, Cregeen RJ (1987) Ibopamine (SKαF 100168) pharmacokinetics in relation to the timing of meals. Br J Clin Pharmacol 23: 585–587

    Google Scholar 

  • Taylor T, Taylor IW, Chasseaud LF, Bonn R (1987) Pharmacokinetics and metabolism of organic nitrate vasodilators. In: Bridges JW, Chasseaud LF, Gibson GG (eds) Progress in drug metabolism, vol 10, Taylor and Francis, London, pp 207–336

    Google Scholar 

  • Ventresca GP, Lodola E (1988) Clinical pharmacokinetics of ibopamine on different diseases and conditions. Drug Res 38: 1175–1180

    Google Scholar 

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Lefebvre, R.A., De Wilde, G., Rosseel, M.T. et al. Investigation of a possible pharmacokinetic interaction between ibopamine and isosorbide-5-mononitrate. Eur J Clin Pharmacol 42, 549–552 (1992). https://doi.org/10.1007/BF00314867

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