Summary
A clinical follow-up covering a period of 5–10 years after onset was performed in 150 patients with optic neuritis or other potential onset symptoms of MS. Thin-layer isoelectric focusing had been used for the initial CSF-protein analysis. No evidence for a more probable alternative diagnosis appeared in 147 patients while a non-MS diagnosis was established in 3 patients. Among these 147 subjects the planned follow-up was accomplished in 131 patients, but not in 16. An evolution into clinically definite MS occurred in 59 subjects, in whom oligoclonal CSF immunoglobulin was found in 92%. Further clinical activity without spatial dissemination—i.e. lesser degrees of diagnostic probability for MS—were found in 35 patients in whom oligoclonal CSF immunoglobulin components were detected in 86%. Among the 131 patients with a complete follow-up, 45 remained free from further clinical activity; oligoclonal CSF immunoglobulin components occurred in 40% of these patients. The frequency of further clinical activity with or without spatial dissemination was significantly higher in subjects exhibiting oligoclonal CSF immunoglobulin components than in those without such changes.
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The initial part of the investigation was performed at the Department of Neurology, Karolinska Hospital, Stockholm, Sweden
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Ersmark, B., Sidén, Å. Isoelectric focusing of CSF proteins and the future evolution of multiple sclerosis: a clinical follow-up. J Neurol 231, 117–121 (1984). https://doi.org/10.1007/BF00313677
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DOI: https://doi.org/10.1007/BF00313677